Assessment of Styrene Oxide Neurotoxicity Using In Vitro Auditory Cortex Networks

PDF Version Also Available for Download.

Description

Article on the assessment of styrene oxide neurotoxicity using in vitro auditory cortex networks.

Physical Description

8 p. : ill.

Creation Information

Gopal, Kamakshi V.; Wu, Calvin; Moore, Ernest J. & Gross, Guenter W. July 6, 2011.

Context

This article is part of the collection entitled: UNT Scholarly Works and was provided by UNT College of Arts and Sciences to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 20 times . More information about this article can be viewed below.

Who

People and organizations associated with either the creation of this article or its content.

Authors

Publisher

Provided By

UNT College of Arts and Sciences

The UNT College of Arts and Sciences educates students in traditional liberal arts, performing arts, sciences, professional, and technical academic programs. In addition to its departments, the college includes academic centers, institutes, programs, and offices providing diverse courses of study.

Contact Us

What

Descriptive information to help identify this article. Follow the links below to find similar items on the Digital Library.

Degree Information

Description

Article on the assessment of styrene oxide neurotoxicity using in vitro auditory cortex networks.

Physical Description

8 p. : ill.

Notes

Abstract: Styrene oxide (SO) (C₈H₈O), the major metabolite of styrene (C₆H₅CH=CH₂), is widely used in industrial applications. Styrene and SO are neurotoxic and cause damaging effects on the auditory system. However, little is known about their concentration-dependent electrophysiological and morphological effects. We used spontaneously active auditory cortex networks (ACNs) growing on microelectrode arrays (MEA) to characterize neurotoxic effects of SO. Acute application of 0.1 to 3.0 mM SO showed concentration-dependent inhibition of spike activity with no noticeable morphological changes. The spike rate IC₅₀ (concentration inducing 50% inhibition) was 511 ± 60 μM (n =10). Subchronic (5 hr) single applications of 0.5 mM SO also showed 50% activity reduction with no overt changes in morphology. The results imply that electrophysiological toxicity precedes cytotoxicity. Five-hour exposures to 2 mM SO revealed neuronal death, irreversible activity loss, and pronounced glial swelling. Paradoxical "protection" by 40 μM bicuculline suggests binding of SO to GABA receptors.

Source

  • International Scholarly Research Notices Otolaryngology, 2011, Nasr City: Hindawi Publishing Corporation

Language

Item Type

Identifier

Unique identifying numbers for this article in the Digital Library or other systems.

Publication Information

  • Publication Title: International Scholarly Research Notices Otolaryngology
  • Volume: 2011
  • Pages: 8
  • Peer Reviewed: Yes

Collections

This article is part of the following collection of related materials.

UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

What responsibilities do I have when using this article?

When

Dates and time periods associated with this article.

Submitted Date

  • May 24, 2011

Accepted Date

  • July 6, 2011

Creation Date

  • July 6, 2011

Added to The UNT Digital Library

  • Aug. 29, 2014, 2:16 p.m.

Usage Statistics

When was this article last used?

Yesterday: 0
Past 30 days: 3
Total Uses: 20

Interact With This Article

Here are some suggestions for what to do next.

Start Reading

PDF Version Also Available for Download.

Citations, Rights, Re-Use

Gopal, Kamakshi V.; Wu, Calvin; Moore, Ernest J. & Gross, Guenter W. Assessment of Styrene Oxide Neurotoxicity Using In Vitro Auditory Cortex Networks, article, July 6, 2011; [Nasr City, Cairo]. (digital.library.unt.edu/ark:/67531/metadc333043/: accessed September 20, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.