Detecting Evolutionary Strata on the Human X Chromosome in the Absence of Gametologous Y-Linked Sequences

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Article on detecting evolutionary strata on the human X chromosome in the absence of gametologous Y-linked sequences.

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9 p.

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Pandey, Ravi Shanker; Sayres, Melissa A. Wilson & Azad, Rajeev K. September 9, 2013.

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Article on detecting evolutionary strata on the human X chromosome in the absence of gametologous Y-linked sequences.

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9 p.

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Abstract: Mammalian sex chromosomes arose from a pair of homologous autosomes that differentiated into the X and Y chromosomes following a series of recombination suppression events between the X and Y. The stepwise recombination suppressions from the distal long arm to the distal short arm of the chromosomes are reflected as regions with distinct X-Y divergence, referred to as evolutionary strata on the X. All current methods for stratum detection depend on X-Y comparisons but are severely limited by the paucity of X-Y gametologs. We have developed an integrative method that combines a top down, recursive segmentation algorithm with a bottom up, agglomerative clustering algorithm to decipher compositionally distinct regions on the X, which reflect regions of unique X-Y divergence. In application to human X chromosome, our method correctly classified a concatenated set of 35 previously assayed X-linked gene sequences by evolutionary strata. We then extended our analysis, applying this method to the entire sequence of the human X chromosome, in an effort to define stratum boundaries. The boundaries of more recently formed strata on X-added region, namely the fourth and fifth strata, have been defined by previous studies and are recapitulated with our method. The older strata, from the first up to the third stratum, have remained poorly resolved due to paucity of X-Y gametologs. By analyzing the entire X sequence, our method identified seven evolutionary strata in these ancient regions, where only three could previously be assayed, thus demonstrating the robustness of our method in detecting the evolutionary strata.

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  • Genome Biology and Evolution, 2013, Oxford: Oxford University Press, pp. 1863-1871

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  • Publication Title: Genome Biology and Evolution
  • Volume: 5
  • Issue: 10
  • Page Start: 1863
  • Page End: 1871
  • Peer Reviewed: Yes

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  • September 9, 2013

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  • Aug. 29, 2014, 2:16 p.m.

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Pandey, Ravi Shanker; Sayres, Melissa A. Wilson & Azad, Rajeev K. Detecting Evolutionary Strata on the Human X Chromosome in the Absence of Gametologous Y-Linked Sequences, article, September 9, 2013; [Oxford, England]. (digital.library.unt.edu/ark:/67531/metadc333031/: accessed August 19, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.