Endocannabinoid System in a Planarian Model

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In this study, the presence and possible function of endocannabinoid ligands in the planarian is investigated. The endocannabinoids ananadamide (AEA) and 2-arachidonoylglycerol (2-AG) and entourage NAE compounds palmitoylethanolamide (PEA), stearoylethanolamide (SEA) and oleoylethanolamide (OEA) were found in Dugesia dorotocephala. Changes in SEA, PEA, and AEA levels were observed over the initial twelve hours of active regeneration. Exogenously applied AEA, 2-AG and their catabolic inhibition effected biphasic changes in locomotor velocity, analogous to those observed in murines. The genome of a close relative, Schmidtea mediterranea, courtesy of the University of Utah S. med genome database, was explored for cannabinoid receptors, none ... continued below

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ix, 138 p.: ill.

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Mustonen, Katie Lynn December 2010.

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This thesis is part of the collection entitled: UNT Theses and Dissertations and was provided by UNT Libraries to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 914 times , with 4 in the last month . More information about this thesis can be viewed below.

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  • Mustonen, Katie Lynn

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In this study, the presence and possible function of endocannabinoid ligands in the planarian is investigated. The endocannabinoids ananadamide (AEA) and 2-arachidonoylglycerol (2-AG) and entourage NAE compounds palmitoylethanolamide (PEA), stearoylethanolamide (SEA) and oleoylethanolamide (OEA) were found in Dugesia dorotocephala. Changes in SEA, PEA, and AEA levels were observed over the initial twelve hours of active regeneration. Exogenously applied AEA, 2-AG and their catabolic inhibition effected biphasic changes in locomotor velocity, analogous to those observed in murines. The genome of a close relative, Schmidtea mediterranea, courtesy of the University of Utah S. med genome database, was explored for cannabinoid receptors, none were found. A putative fatty acid amide hydrolase (FAAH) homolog was found in Schmidtea mediterranea.

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ix, 138 p.: ill.

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UNT Theses and Dissertations

Theses and dissertations represent a wealth of scholarly and artistic content created by masters and doctoral students in the degree-seeking process. __Some ETDs in this collection are restricted to use by the UNT community__.

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  • December 2010

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  • May 4, 2011, 1:11 p.m.

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  • Aug. 2, 2011, 4:17 p.m.

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Citations, Rights, Re-Use

Mustonen, Katie Lynn. Endocannabinoid System in a Planarian Model, thesis, December 2010; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc33188/: accessed February 26, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .