A Study of Polynuclear Aromatic Hydrocarbon Carcinogen Transport and Deoxyribonucleic Acid Repair Page: 3
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absolutely required for the activation of DNA polymerase-a,
which is the major enzyme of DNA excision repair necessary
to correct the DNA damage caused by BaP.
This study concludes that an active metabolite of the
polynuclear aromatic hydrocarbon carcinogen, benzo(a)pyrene,
suppresses DNA polymerase-a activity by inhibiting the
binding of 21-deoxyguanosine 51-triphosphate to an acceptor
site on the DNA polymerase-a complex with the DNA substrate,
thereby competitively inhibiting interaction of 2'-deoxy-
guanosine 51-triphosphate in the DNA synthetic process.
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Joe, Cheol O., 1949-. A Study of Polynuclear Aromatic Hydrocarbon Carcinogen Transport and Deoxyribonucleic Acid Repair, dissertation, December 1984; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc331755/m1/3/: accessed December 12, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .