A Study of Polynuclear Aromatic Hydrocarbon Carcinogen Transport and Deoxyribonucleic Acid Repair Page: 3
The following text was automatically extracted from the image on this page using optical character recognition software:
absolutely required for the activation of DNA polymerase-a,
which is the major enzyme of DNA excision repair necessary
to correct the DNA damage caused by BaP.
This study concludes that an active metabolite of the
polynuclear aromatic hydrocarbon carcinogen, benzo(a)pyrene,
suppresses DNA polymerase-a activity by inhibiting the
binding of 21-deoxyguanosine 51-triphosphate to an acceptor
site on the DNA polymerase-a complex with the DNA substrate,
thereby competitively inhibiting interaction of 2'-deoxy-
guanosine 51-triphosphate in the DNA synthetic process.
Here’s what’s next.
This dissertation can be searched. Note: Results may vary based on the legibility of text within the document.
Tools / Downloads
Get a copy of this page or view the extracted text.
Citing and Sharing
Basic information for referencing this web page. We also provide extended guidance on usage rights, references, copying or embedding.
Reference the current page of this Dissertation.
Joe, Cheol O., 1949-. A Study of Polynuclear Aromatic Hydrocarbon Carcinogen Transport and Deoxyribonucleic Acid Repair, dissertation, December 1984; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc331755/m1/3/: accessed March 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .