Functional Neural Toxicity and Endocrine Responses in Mice Following Naphthalene Exposure

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Polycyclic aromatic hydrocarbons (PAHs) are a well studied and diverse class of environmental toxicants. PAHs act via the aryl hydrocarbon receptor (AhR), and studies have suggested that PAHs may elicit neurological and estrogenic effects. Doses of PAHs between 50 to 150 ppm may elicit neurotoxicity in rodent models. The present study investigated the effects of naphthalene on in vivo steroidogenesis in Swiss Webster male mice, and in vitro neural function of Balb-C/ICR mice frontal cortex neurons. These data suggest that naphthalene may not elicit steroidogenic effects at concentrations ranging from 0.2 to 25 mg/kg/day, following a 7 day subcutaneous dosing ... continued below

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v, 55 p. : ill.

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Colbert, Crystal August 2010.

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This thesis is part of the collection entitled: UNT Theses and Dissertations and was provided by UNT Libraries to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 310 times , with 6 in the last month . More information about this thesis can be viewed below.

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  • Colbert, Crystal

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Polycyclic aromatic hydrocarbons (PAHs) are a well studied and diverse class of environmental toxicants. PAHs act via the aryl hydrocarbon receptor (AhR), and studies have suggested that PAHs may elicit neurological and estrogenic effects. Doses of PAHs between 50 to 150 ppm may elicit neurotoxicity in rodent models. The present study investigated the effects of naphthalene on in vivo steroidogenesis in Swiss Webster male mice, and in vitro neural function of Balb-C/ICR mice frontal cortex neurons. These data suggest that naphthalene may not elicit steroidogenic effects at concentrations ranging from 0.2 to 25 mg/kg/day, following a 7 day subcutaneous dosing regime. In addition, naphthalene may cause functional toxicity of frontal cortex neurons at concentrations of 32 to 160 ppm naphthalene.

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v, 55 p. : ill.

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  • August 2010

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  • March 30, 2011, 9:15 p.m.

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  • June 27, 2017, 11:18 a.m.

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Colbert, Crystal. Functional Neural Toxicity and Endocrine Responses in Mice Following Naphthalene Exposure, thesis, August 2010; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc31529/: accessed August 19, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .