Intraocular Pressure Changes: An Important Determinant of the Biocompatibility of Intravitreous Implants Metadata

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Title

  • Main Title Intraocular Pressure Changes: An Important Determinant of the Biocompatibility of Intravitreous Implants

Creator

  • Author: Zou, Ling
    Creator Type: Personal
    Creator Info: University of Texas Southwestern Medical School at Dallas; University of Texas at Arlington
  • Author: Nair, Ashwin
    Creator Type: Personal
    Creator Info: University of Texas Southwestern Medical School at Dallas; University of Texas at Arlington
  • Author: Weng, Hong
    Creator Type: Personal
    Creator Info: University of Texas Southwestern Medical School at Dallas; University of Texas at Arlington
  • Author: Tsai, Yi-Ting
    Creator Type: Personal
    Creator Info: University of Texas Southwestern Medical School at Dallas; University of Texas at Arlington
  • Author: Hu, Zhibing
    Creator Type: Personal
    Creator Info: University of North Texas
  • Author: Tang, Liping
    Creator Type: Personal
    Creator Info: University of Texas Southwestern Medical School at Dallas; University of Texas at Arlington

Publisher

  • Name: Public Library of Science
    Place of Publication: [San Francisco, California]

Date

  • Creation: 2011-12-14

Language

  • English

Description

  • Content Description: Article discussing intraocular pressure changes and an important determinant of the biocompatibility of intravitreous implants.
  • Physical Description: 9 p.

Subject

  • Keyword: biomaterial nanoparticles
  • Keyword: intravitreous drug delivery
  • Keyword: intraocular pressure

Source

  • Journal: PLoS One, 2011, San Francisco: Public Library of Science

Citation

  • Publication Title: PLoS One
  • Volume: 6
  • Issue: 12
  • Pages: 9
  • Peer Reviewed: True

Collection

  • Name: UNT Scholarly Works
    Code: UNTSW

Institution

  • Name: UNT College of Arts and Sciences
    Code: UNTCAS

Rights

  • Rights Access: public
  • Rights License: by

Resource Type

  • Article

Format

  • Text

Identifier

  • DOI: 10.1371/journal.pone.0028720
  • Archival Resource Key: ark:/67531/metadc288003

Degree

  • Academic Department: Physics

Note

  • Display Note: Abstract: Background: In recent years, research efforts exploring the possibility of using biomaterial nanoparticles for intravitreous drug delivery has increased significantly. However, little is known about the effect of material properties on intravitreous tissue responses. Principal Findings: To find the answer, nanoparticles made of hyaluronic acid (HA), poly (l-lactic acid) (PLLA), polystyrene (PS), and Poly N-isopropyl acrylamide (PNIPAM) were tested using intravitreous rabbit implantation model. Shortly after implantation, we found that most of the implants accumulated in the trabecular meshwork area followed by clearance from the vitreous. Interestingly, substantial reduction of intraocular pressure (IOP) was observed in eyes implanted with particles made of PS, PNIPAM and PLLA, but not HA nanoparticles and buffered salt solution control. On the other hand, based on histology, we found that the particle implantation had no influence on cornea, iris and even retina. Surprisingly, substantial CD11b+ inflammatory cells were found to accumulate in the trabecular meshwork area in some animals. In addition, there was a good relationship between recruited CD11b+ cells and IOP reduction. Conclusions: Overall, the results reveal the potential influence of nanoparticle material properties on IOP reduction and inflammatory responses in trabecular meshwork. Such interactions may be critical for the development of future ocular nanodevices with improved safety and perhaps efficacy.