Intraocular Pressure Changes: An Important Determinant of the Biocompatibility of Intravitreous Implants Metadata
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- Main Title Intraocular Pressure Changes: An Important Determinant of the Biocompatibility of Intravitreous Implants
Author: Zou, LingCreator Type: PersonalCreator Info: University of Texas Southwestern Medical School at Dallas; University of Texas at Arlington
Author: Nair, AshwinCreator Type: PersonalCreator Info: University of Texas Southwestern Medical School at Dallas; University of Texas at Arlington
Author: Weng, HongCreator Type: PersonalCreator Info: University of Texas Southwestern Medical School at Dallas; University of Texas at Arlington
Author: Tsai, Yi-TingCreator Type: Personal
Author: Hu, ZhibingCreator Type: PersonalCreator Info: University of North Texas
Author: Tang, LipingCreator Type: Personal
Name: Public Library of SciencePlace of Publication: [San Francisco, California]
- Creation: 2011-12-14
- Content Description: Article discussing intraocular pressure changes and an important determinant of the biocompatibility of intravitreous implants.
- Physical Description: 9 p.
- Keyword: biomaterial nanoparticles
- Keyword: intravitreous drug delivery
- Keyword: intraocular pressure
- Journal: PLoS One, 2011, San Francisco: Public Library of Science
- Publication Title: PLoS One
- Volume: 6
- Issue: 12
- Pages: 9
- Peer Reviewed: True
Name: UNT Scholarly WorksCode: UNTSW
Name: UNT College of Arts and SciencesCode: UNTCAS
- Rights Access: public
- Rights License: by
- DOI: 10.1371/journal.pone.0028720
- Archival Resource Key: ark:/67531/metadc288003
- Academic Department: Physics
- Display Note: Abstract: Background: In recent years, research efforts exploring the possibility of using biomaterial nanoparticles for intravitreous drug delivery has increased significantly. However, little is known about the effect of material properties on intravitreous tissue responses. Principal Findings: To find the answer, nanoparticles made of hyaluronic acid (HA), poly (l-lactic acid) (PLLA), polystyrene (PS), and Poly N-isopropyl acrylamide (PNIPAM) were tested using intravitreous rabbit implantation model. Shortly after implantation, we found that most of the implants accumulated in the trabecular meshwork area followed by clearance from the vitreous. Interestingly, substantial reduction of intraocular pressure (IOP) was observed in eyes implanted with particles made of PS, PNIPAM and PLLA, but not HA nanoparticles and buffered salt solution control. On the other hand, based on histology, we found that the particle implantation had no influence on cornea, iris and even retina. Surprisingly, substantial CD11b+ inflammatory cells were found to accumulate in the trabecular meshwork area in some animals. In addition, there was a good relationship between recruited CD11b+ cells and IOP reduction. Conclusions: Overall, the results reveal the potential influence of nanoparticle material properties on IOP reduction and inflammatory responses in trabecular meshwork. Such interactions may be critical for the development of future ocular nanodevices with improved safety and perhaps efficacy.