Intraocular Pressure Changes: An Important Determinant of the Biocompatibility of Intravitreous Implants

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Article discussing intraocular pressure changes and an important determinant of the biocompatibility of intravitreous implants.

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9 p.

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Zou, Ling; Nair, Ashwin; Weng, Hong; Tsai, Yi-Ting; Hu, Zhibing & Tang, Liping December 14, 2011.

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  • Zou, Ling University of Texas Southwestern Medical School at Dallas; University of Texas at Arlington
  • Nair, Ashwin University of Texas Southwestern Medical School at Dallas; University of Texas at Arlington
  • Weng, Hong University of Texas Southwestern Medical School at Dallas; University of Texas at Arlington
  • Tsai, Yi-Ting University of Texas Southwestern Medical School at Dallas; University of Texas at Arlington
  • Hu, Zhibing University of North Texas
  • Tang, Liping University of Texas Southwestern Medical School at Dallas; University of Texas at Arlington

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Article discussing intraocular pressure changes and an important determinant of the biocompatibility of intravitreous implants.

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9 p.

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Abstract: Background: In recent years, research efforts exploring the possibility of using biomaterial nanoparticles for intravitreous drug delivery has increased significantly. However, little is known about the effect of material properties on intravitreous tissue responses. Principal Findings: To find the answer, nanoparticles made of hyaluronic acid (HA), poly (l-lactic acid) (PLLA), polystyrene (PS), and Poly N-isopropyl acrylamide (PNIPAM) were tested using intravitreous rabbit implantation model. Shortly after implantation, we found that most of the implants accumulated in the trabecular meshwork area followed by clearance from the vitreous. Interestingly, substantial reduction of intraocular pressure (IOP) was observed in eyes implanted with particles made of PS, PNIPAM and PLLA, but not HA nanoparticles and buffered salt solution control. On the other hand, based on histology, we found that the particle implantation had no influence on cornea, iris and even retina. Surprisingly, substantial CD11b+ inflammatory cells were found to accumulate in the trabecular meshwork area in some animals. In addition, there was a good relationship between recruited CD11b+ cells and IOP reduction. Conclusions: Overall, the results reveal the potential influence of nanoparticle material properties on IOP reduction and inflammatory responses in trabecular meshwork. Such interactions may be critical for the development of future ocular nanodevices with improved safety and perhaps efficacy.

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  • PLoS One, 2011, San Francisco: Public Library of Science

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  • Publication Title: PLoS One
  • Volume: 6
  • Issue: 12
  • Pages: 9
  • Peer Reviewed: Yes

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UNT Scholarly Works

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  • December 14, 2011

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  • June 6, 2014, 11:19 a.m.

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  • Aug. 29, 2014, 10:04 a.m.

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Zou, Ling; Nair, Ashwin; Weng, Hong; Tsai, Yi-Ting; Hu, Zhibing & Tang, Liping. Intraocular Pressure Changes: An Important Determinant of the Biocompatibility of Intravitreous Implants, article, December 14, 2011; [San Francisco, California]. (digital.library.unt.edu/ark:/67531/metadc288003/: accessed December 15, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.