Zebrafish Thrombocytes: Functions and Origins

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Article integrating the information available on zebrafish thrombocyte function and its formation.

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9 p.

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Khandekar, Gauri; Kim, Seongcheol & Jagadeeswaran, Pudur 2012.

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This article is part of the collection entitled: UNT Scholarly Works and was provided by UNT College of Arts and Sciences to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 143 times , with 6 in the last month . More information about this article can be viewed below.

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Article integrating the information available on zebrafish thrombocyte function and its formation.

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9 p.

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Abstract: Platelets play an important role in mammalian hemostasis. Thrombocytes of early vertebrates are functionally equivalent to mammalian platelets. A substantial amount of research has been done to study platelet function in humans as well as in animal models. However, to date only limited functional genomic studies of platelets have been performed but are low throughput and are not cost-effective. Keeping this in mind we introduced zebrafish, a vertebrate genetic model to study platelet function. We characterized zebrafish thrombocytes and established functional assays study not only their hemostatic function but to also their production. We identified a few genes which play a role in their function and production. Since we introduced the zebrafish model for the study of hemostasis and thrombosis, other groups have adapted this model to study genes that are associated with thrombocyte function and a few novel genes have also been identified. Furthermore, transgenic zebrafish with GFP-tagged thrombocytes have been developed which helped to study the production of thrombocytes and their precursors as well as their functional roles not only in hemostasis but also hematopoiesis. This paper integrates the information available on zebrafish thrombocyte function and its formation.

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  • Advances in Hematology, 2012, Nasr City: Hindawi Publishing Corporation

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  • Publication Title: Advances in Hematology
  • Volume: 2012
  • Pages: 9
  • Peer Reviewed: Yes

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UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

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  • 2012

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  • June 6, 2014, 11:19 a.m.

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Khandekar, Gauri; Kim, Seongcheol & Jagadeeswaran, Pudur. Zebrafish Thrombocytes: Functions and Origins, article, 2012; [Nasr City, Cairo]. (digital.library.unt.edu/ark:/67531/metadc288001/: accessed November 16, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.