Sodium and Potassium Currents of Type I Spiral Ganglion Cells from Rat

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Article discussing sodium and potassium currents of type I spiral ganglion cells from rat.

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9 p.

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Moore, Ernest J.; Hall, Deanne B. & Narahashi, Toshio 1996.

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Article discussing sodium and potassium currents of type I spiral ganglion cells from rat.

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9 p.

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Abstract: Ion channel activity of acutely dissociated type I spiral ganglion cells isolated from rats was investigated using the whole-cell variation of the patch clamp technique. Tetrodotoxin-sensitive sodium current and tetraethylammonium-sensitive potassium current were recorded. With a holding potential of -80 mV, peak sodium currents were generated by depolarizations to membrane potentials more positive than -50 mV. Potassium currents were elicited at membrane potentials more positive than -40 mV. Some cells which did not exhibit sodium current exhibited delayed rectifier potassium currents. Steady-state sodium channel inactivation curve yielded a slope of 12 mV and a half-inactivated potential of -83 mV. Recovery from inactivation of the sodium channel proceeded with a fast and slow time course; recovery began as early as 0.8 ms and proceeded with a time constant of 7.5 ms. It is concluded that type I spiral ganglion cells are endowed with sodium and potassium channels which are responsible for generation and propagation of auditory nerve action potentials.

Copyright © 1996 Scandinavian University Press.

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  • Acta Otolaryngol (Stockh), 1996, Oslo: Scandinavian University Press, pp. 552-560

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  • Publication Title: Acta Otolaryngol (Stockh)
  • Volume: 16
  • Issue: 4
  • Page Start: 552
  • Page End: 560

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  • 1996

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  • June 6, 2014, 11:19 a.m.

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Moore, Ernest J.; Hall, Deanne B. & Narahashi, Toshio. Sodium and Potassium Currents of Type I Spiral Ganglion Cells from Rat, article, 1996; [Oslo, Norway]. (digital.library.unt.edu/ark:/67531/metadc287997/: accessed October 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.