Garcinol, a Polyisoprenylated Benzophenone Modulates Multiple Proinflammatory Signaling Cascades Leading to the Suppression of Growth and Survival of Head and Neck Carcinoma

PDF Version Also Available for Download.

Description

Article on the constitutive activation of proinflammatory transcription factors such as STAT3 and NF-KB that play a pivotal role in the proliferation and survival of squamous cell carcinoma of the head and neck (HNSCC).

Physical Description

12 p.

Creation Information

Li, Feng; Shanmugam, Muthu K.; Chen, Luxi; Chatterjee, Snehajyoti; Basha, Jeelan; Kumar, Alan Prem et al. June 26, 2013.

Context

This article is part of the collection entitled: UNT Scholarly Works and was provided by UNT College of Arts and Sciences to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 68 times . More information about this article can be viewed below.

Who

People and organizations associated with either the creation of this article or its content.

Authors

  • Li, Feng National University of Singapore
  • Shanmugam, Muthu K. National University of Singapore
  • Chen, Luxi National University of Singapore; Cancer Science Institute of Singapore
  • Chatterjee, Snehajyoti Jawaharlal Nehru Centre for Advanced Scientific Research
  • Basha, Jeelan Jawaharlal Nehru Centre for Advanced Scientific Research
  • Kumar, Alan Prem University of North Texas; National University of Singapore; Cancer Science Institute of Singapore; Curtin University
  • Kundu, Tapas K. Jawaharlal Nehru Centre for Advanced Scientific Research
  • Sethi, Gautam National University of Singapore; Cancer Science Institute of Singapore

Publisher

Provided By

UNT College of Arts and Sciences

The UNT College of Arts and Sciences educates students in traditional liberal arts, performing arts, sciences, professional, and technical academic programs. In addition to its departments, the college includes academic centers, institutes, programs, and offices providing diverse courses of study.

Contact Us

What

Descriptive information to help identify this article. Follow the links below to find similar items on the Digital Library.

Degree Information

Description

Article on the constitutive activation of proinflammatory transcription factors such as STAT3 and NF-KB that play a pivotal role in the proliferation and survival of squamous cell carcinoma of the head and neck (HNSCC).

Physical Description

12 p.

Notes

Abstract: Constitutive activation of proinflammatory transcription factors such as STAT3 and NF-KB plays a pivotal role in the proliferation and survival of squamous cell carcinoma of the head and neck (HNSCC). Thus, the agents that can modulate deregulated STAT3 and NF-KB activation have a great potential both for the prevention and treatment of HNSCC. In the present report, we investigated the potential effects of garcinol, an active component of Garcinia indica on various inflammatory mediators involved in HNSCC progression using cell lines and xenograft mouse model. We found that garcinol inhibited constitutively activated STAT3 in HNSCC cells in a time- and dose-dependent manner, which correlated with the suppression of the upstream kinases (c-Src, JAK1, and JAK2) in HNSCC cells. Also, we noticed that the generation of reactive oxygen species is involved in STAT3 inhibitory effect of garcinol. Furthermore, garcinol exhibited an inhibitory effect on the constitutive NF-KB activation, mediated through the suppression of TGF-β-activated kinase 1 (TAK1) and inhibitor of 1KB kinase (IKK) activation in HNSCC cells. When administered intraperitoneally, garcinol inhibited the growth of human HNSCC xenograft tumors in male athymic nu/nu mice. Overall, our results suggest for the first time that garcinol mediates its antitumor effects in HNSCC cells and mouse model through the suppression of multiple proinflammatory cascades.

Copyright © 2013 American Association for Cancer Research. www.aacrjournals.org

Source

  • Cancer Prevention Research, 2013, Philadelphia: American Association for Cancer Research, pp. 843-854

Language

Item Type

Identifier

Unique identifying numbers for this article in the Digital Library or other systems.

Publication Information

  • Publication Title: Cancer Prevention Research
  • Volume: 6
  • Issue: 8
  • Page Start: 843
  • Page End: 854
  • Peer Reviewed: Yes

Collections

This article is part of the following collection of related materials.

UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

What responsibilities do I have when using this article?

When

Dates and time periods associated with this article.

Creation Date

  • June 26, 2013

Added to The UNT Digital Library

  • May 29, 2014, 5:29 p.m.

Usage Statistics

When was this article last used?

Yesterday: 0
Past 30 days: 0
Total Uses: 68

Interact With This Article

Here are some suggestions for what to do next.

Start Reading

PDF Version Also Available for Download.

International Image Interoperability Framework

IIF Logo

We support the IIIF Presentation API

Li, Feng; Shanmugam, Muthu K.; Chen, Luxi; Chatterjee, Snehajyoti; Basha, Jeelan; Kumar, Alan Prem et al. Garcinol, a Polyisoprenylated Benzophenone Modulates Multiple Proinflammatory Signaling Cascades Leading to the Suppression of Growth and Survival of Head and Neck Carcinoma, article, June 26, 2013; [Philadelphia, Pennsylvania]. (digital.library.unt.edu/ark:/67531/metadc287063/: accessed October 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.