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Article discussing the I' potential of the human auditory brainstem response to paired click stimuli.
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11 p.
Notes
Abstract: When stimulated with an appropriate stimulus, the hair cells of the organ of Corti depolarize, causing the release of a neurotransmitter substance, which excites afferent VIIIth nerve dendrites. It is reasonable to hypothesize that excitatory postsynaptic potentials (EPSPs) generated by the dendrites of the auditory nerve in turn initiate a compound action potential (CAP). The EPSP is thought to be the generator potential for the CAP, and may be recorded in auditory brainstem responses (ABRs) as the I' potential. Determining the anatomical origin of I' may enhance the sensitivity of the ABR technique in hair cell/dendrite/auditory nerve evaluations. Whether I' is of sensory or of neural origin is equivocal, and therefore I' is not well understood. To investigate this dilemma, ABRs were recorded from human subjects using standard and paired-click stimuli, and using subtraction methods to generate a derived ABR. Two early peaks, designated as I degree and I', occurred before wave I in the derived ABR. It was hypothesized that peaks I degrees and I' represent the summating potential and the generator potential, generated by the cochlea and VIIIth nerve dendrites, respectively.
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Davis-Gunter, Misha J.; Löwenheim, Hubert; Gopal, Kamakshi V. & Moore, Ernest J.The I' potential of the human auditory brainstem response to paired click stimuli,
article,
2001;
[New York, New York].
(digital.library.unt.edu/ark:/67531/metadc287053/:
accessed April 25, 2018),
University of North Texas Libraries, Digital Library, digital.library.unt.edu;
crediting UNT College of Arts and Sciences.