D-Methionine protects against cisplatin-induced neurotoxicity in cortical networks

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Article discussing D-Methionine protecting against cisplatin-induced neurotoxicity in cortical networks.

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10 p.

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Gopal, Kamakshi V.; Wu, Calvin; Shrestha, Bibesh; Campbell, Kathleen C. M.; Moore, Ernest J. & Gross, Guenter W. June 23, 2012.

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Article discussing D-Methionine protecting against cisplatin-induced neurotoxicity in cortical networks.

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10 p.

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Abstract: When stimulated with an appropriate stimulus, the hair cells of the organ of Corti depolarize, causing the release of a neurotransmitter substance, which excites afferent VIIIth nerve dendrites. It is reasonable to hypothesize that excitatory postsynaptic potentials (EPSPs) generated by the dendrites of the auditory nerve in turn initiate a compound action potential (CAP). The EPSP is thought to be the generator potential for the CAP, and may be recorded in auditory brainstem responses (ABRs) as the I' potential. Determining the anatomical origin of I' may enhance the sensitivity of the ABR technique in hair cell/dendrite/auditory nerve evaluations. Whether I' is of sensory or of neural origin is equivocal, and therefore I' is not well understood. To investigate this dilemma, ABRs were recorded from human subjects using standard and paired-click stimuli, and using subtraction methods to generate a derived ABR. Two early peaks, designated as I degree and I', occurred before wave I in the derived ABR. It was hypothesized that peaks I degrees and I' represent the summating potential and the generator potential, generated by the cochlea and VIIIth nerve dendrites, respectively.

Copyright © 2012 Elsevier Science Ltd., all rights reserved. http://dx.doi.org/10.1016/j.ntt.2012.06.002

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  • Neurotoxicology and Teratology, 2012, Amsterdam: Elsevier Science Ltd., pp. 495-504

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  • Publication Title: Neurotoxicology and Teratology
  • Volume: 34
  • Page Start: 495
  • Page End: 504
  • Peer Reviewed: Yes

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  • June 23, 2012

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  • May 29, 2014, 5:29 p.m.

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Gopal, Kamakshi V.; Wu, Calvin; Shrestha, Bibesh; Campbell, Kathleen C. M.; Moore, Ernest J. & Gross, Guenter W. D-Methionine protects against cisplatin-induced neurotoxicity in cortical networks, article, June 23, 2012; [Amsterdam, Netherlands]. (digital.library.unt.edu/ark:/67531/metadc287047/: accessed October 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.