Inhibition of K+ currents of outer hair cells in guinea pig cochlea by fluoxetine

PDF Version Also Available for Download.

Description

Article discussing the inhibition of K+ currents of outer hair cells in guinea pig cochlea by fluoxetine.

Physical Description

8 p.

Creation Information

Bian, Jing-Tan; Yeh, Jay Z.; Aistrup, Gary L.; Narahashi, Toshio & Moore, Ernest J. October 25, 2002.

Context

This article is part of the collection entitled: UNT Scholarly Works and was provided by UNT College of Arts and Sciences to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 181 times , with 5 in the last month . More information about this article can be viewed below.

Who

People and organizations associated with either the creation of this article or its content.

Authors

Publisher

Provided By

UNT College of Arts and Sciences

The UNT College of Arts and Sciences educates students in traditional liberal arts, performing arts, sciences, professional, and technical academic programs. In addition to its departments, the college includes academic centers, institutes, programs, and offices providing diverse courses of study.

Contact Us

What

Descriptive information to help identify this article. Follow the links below to find similar items on the Digital Library.

Degree Information

Description

Article discussing the inhibition of K+ currents of outer hair cells in guinea pig cochlea by fluoxetine.

Physical Description

8 p.

Notes

Abstract: The effects of fluoxetine (Prozac®), a widely used antidepressant drug, on K+ channel in outer hair cells isolated from guinea pig cochlea were studied using the whole-cell patch clamp technique. Fluoxetine potently inhibited leak K+ currents with an IC50 of 0.78 μM. The inhibition was reversible and voltage-independent. At 45- to 103-fold higher concentrations than the plasma levels, fluoxetine reversibly blocked voltage-activated K+ currents. Kinetics of the current in the presence of fluoxetine resembled the control current, and the inhibition was not use-dependent. Neither the activation curve nor the reversal potential was affected by fluoxetine. This inhibition was voltage-dependent with an electric distance (δ value) of the binding site of at least 26% of the membrane field from the cytoplasmic side. Use-independent inhibition suggests that fluoxetine blocks the channel before its opening or instantly blocks the open channel. This is the first study of the action of this compound on K+ channel of outer hair cells of the mammalian inner ear. We conclude that the block of the leak K+ currents can occur at therapeutic levels of fluoxetine. Since the voltage-activated K+ currents are not potently blocked by fluoxetine, this action might not be related to its antidepressant action or adverse effects.

Copyright © 2002 Elsevier Science Ltd., all rights reserved. http://dx.doi.org/10.1016/S0014-2999(02)02421-4

Source

  • European Journal of Pharmacology, 2002, New York: Elsevier Science Ltd., pp. 159-166

Language

Item Type

Identifier

Unique identifying numbers for this article in the Digital Library or other systems.

Publication Information

  • Publication Title: European Journal of Pharmacology
  • Volume: 453
  • Page Start: 159
  • Page End: 166
  • Peer Reviewed: Yes

Collections

This article is part of the following collection of related materials.

UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

What responsibilities do I have when using this article?

When

Dates and time periods associated with this article.

Creation Date

  • October 25, 2002

Added to The UNT Digital Library

  • May 29, 2014, 5:29 p.m.

Description Last Updated

  • April 1, 2015, 1:52 p.m.

Usage Statistics

When was this article last used?

Yesterday: 0
Past 30 days: 5
Total Uses: 181

Interact With This Article

Here are some suggestions for what to do next.

Start Reading

PDF Version Also Available for Download.

International Image Interoperability Framework

IIF Logo

We support the IIIF Presentation API

Bian, Jing-Tan; Yeh, Jay Z.; Aistrup, Gary L.; Narahashi, Toshio & Moore, Ernest J. Inhibition of K+ currents of outer hair cells in guinea pig cochlea by fluoxetine, article, October 25, 2002; [New York, New York]. (digital.library.unt.edu/ark:/67531/metadc287039/: accessed September 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.