An M-Like Potassium Current in the Guinea Pig Cochlea

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Article discussing an M-like potassium current in the guinea pig cochlea.

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8 p.

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Liang, Guihua; Moore, Ernest J.; Ulfendahl, Mats; Rydqvist, Bo & Järlebark, Leif April 26, 2005.

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Article discussing an M-like potassium current in the guinea pig cochlea.

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8 p.

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Abstract: Potassium M currents play a role in stabilizing the resting membrane potential. These currents have previously been identified in several cell types, including sensory receptors. Given that maintaining membrane excitability is important for mechano-electrical transduction in the inner ear, the presence of M currents was investigated in outer hair cells isolated from the guinea pig hearing organ. Using a pulse protocol designed to emphasize M currents with the whole-cell patch-clamp technique, voltage- and time-dependent, non-inactivating, low-threshold currents (the hallmarks of M currents) were recorded. These currents were significantly reduced by cadmium chloride. Results from RT-PCR analysis indicated that genes encoding M channel subunits KCNQ2 and KCNQ3 are expressed in the guinea pig cochlea. Our data suggest that guinea pig outer hair cells express an M-like potassium current that, following sound stimulation, may play an important role in returning the membrane potential to resting level and thus regulating outer hair cell synaptic mechanisms.

Copyright © 2005 S. Karger AG, Basel. https://www.karger.com/Article/Pdf/85439

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  • Journal for Oto-Rhino-Laryngology (ORL), 2004, Basel: Karger Publishers, pp. 75-82

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  • Publication Title: Journal for Oto-Rhino-Laryngology (ORL)
  • Volume: 67
  • Issue: 2
  • Page Start: 75
  • Page End: 82
  • Peer Reviewed: Yes

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  • April 26, 2005

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  • May 29, 2014, 5:29 p.m.

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Liang, Guihua; Moore, Ernest J.; Ulfendahl, Mats; Rydqvist, Bo & Järlebark, Leif. An M-Like Potassium Current in the Guinea Pig Cochlea, article, April 26, 2005; [Basel, Switzerland]. (digital.library.unt.edu/ark:/67531/metadc287036/: accessed November 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.