Lead (Pb2+) modulation of potassium currents of guinea pig outer hair cells

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Article discussing lead (Pb2+) modulation of potassium currents of guinea pig outer hair cells.

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8 p.

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Liang, Guihua; Järlebark, Leif; Ulfendahl, Mats; Bian, Jing-Tan & Moore, Ernest J. 2004.

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Article discussing lead (Pb2+) modulation of potassium currents of guinea pig outer hair cells.

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Abstract: Outer hair cells (OHC) are mechanosensitive sensory cells of the inner ear cochlea and are involved in modulating the activity of inner hair cells in the transduction of an acoustic stimulus. Potassium (K+) currents play an important role in the sensory transduction process. K+ currents were recorded from acutely dissociated OHC obtained from the guinea pig organ of Corti. The whole-cell patch clamp technique was employed. We identified a channel that exhibited outward current of the delayed rectifier type (Kv). Kv channels mediating inward currents carried by potassium ions were also identified and took on the appearance of a previously described inwardly rectifying current. Lead (Pb2+) acetate at concentrations of 0.1, 1.0, 10, and 100 μM was bath applied. Time to activation for outward-going current was not affected by Pb2+. The time course of Pb2+ effects was seen as a dose-dependent reduction of K+ current over time, with very little or no recovery after washout. Pb2+ inhibited the outward Kv relative current with values of 0.10, 0.14, 0.18, and 0.30 at 0.1, 1.0, 10, and 100 μM, respectively. Pb2+ did not modulate time to activation, peak current, or inactivation of inward IK. The effects of Pb2+ on the potassium currents of OHC are not remarkable and therefore OHC are probably not a major cause of purported peripheral hearing loss observed in Pb2+-exposed animals and humans.

Copyright © 2002 Elsevier Science Ltd., all rights reserved. http://dx.doi.org/10.1016/j.ntt.2003.12.002

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  • Neurotoxicology and Teratology, 2004, New York: Elsevier Science Ltd., pp. 253-260

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  • Publication Title: Neurotoxicology and Teratology
  • Volume: 26
  • Issue: 2
  • Page Start: 253
  • Page End: 260
  • Peer Reviewed: Yes

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  • 2004

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  • May 29, 2014, 5:29 p.m.

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  • April 1, 2015, 3:25 p.m.

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Liang, Guihua; Järlebark, Leif; Ulfendahl, Mats; Bian, Jing-Tan & Moore, Ernest J. Lead (Pb2+) modulation of potassium currents of guinea pig outer hair cells, article, 2004; [New York, New York]. (digital.library.unt.edu/ark:/67531/metadc287032/: accessed July 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.