Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer

PDF Version Also Available for Download.

Description

Article on the targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.

Physical Description

11 p.

Creation Information

Shrimali, Deepti; Shanmugam, Muthu K.; Kumar, Alan Prem; Zhang, Jingwen; Tan, Benny K-H; Ahn, Kwang Seok et al. December 1, 2013.

Context

This article is part of the collection entitled: UNT Scholarly Works and was provided by UNT College of Arts and Sciences to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 488 times . More information about this article can be viewed below.

Who

People and organizations associated with either the creation of this article or its content.

Authors

Publisher

Provided By

UNT College of Arts and Sciences

The UNT College of Arts and Sciences educates students in traditional liberal arts, performing arts, sciences, professional, and technical academic programs. In addition to its departments, the college includes academic centers, institutes, programs, and offices providing diverse courses of study.

Contact Us

What

Descriptive information to help identify this article. Follow the links below to find similar items on the Digital Library.

Degree Information

Description

Article on the targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.

Physical Description

11 p.

Notes

Abstract: Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural occurring anthraquinone derivative isolated from roots and barks of numerous plants, molds, and lichens. It is found as an active ingredient in different Chinese herbs including Rheum palmatum and Polygonam multiflorum, and has diuretic, vasorelaxant, anti-bacterial, anti-viral, anti-ulcerogenic, anti-inflammatory, and anti-cancer effects. The anti-inflammatory effects of emodin have been exhibited in various in vitro as well as in vivo models of inflammation including pancreatitis, arthritis, asthma, atherosclerosis and glomerulonephritis. As an anti-cancer agent, emodin has been shown to suppress the growth of various tumor cell lines including hepatocellular carcinoma, pancreatic, breast, colorectal, leukemia, and lung cancers. Emodin is a pleiotropic molecule capable of interacting with several major molecular targets including NF-κB, casein kinase II, HER2/neu, HIF-1α, AKT/mTOR, STAT3, CXCR4, topoisomerase II, p53, p21, and androgen receptors which are involved in inflammation and cancer. This review summarizes reported anti-inflammatory and anti-cancer effects of emodin, and re-emphasizes its potential therapeutic role in the treatment of inflammatory diseases and cancer.

Source

  • Cancer Letters, 2013, New York: Elsevier Science Ltd., pp. 139-149

Language

Item Type

Identifier

Unique identifying numbers for this article in the Digital Library or other systems.

Publication Information

  • Publication Title: Cancer Letters
  • Volume: 341
  • Issue: 2
  • Page Start: 139
  • Page End: 149
  • Peer Reviewed: Yes

Collections

This article is part of the following collection of related materials.

UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

What responsibilities do I have when using this article?

When

Dates and time periods associated with this article.

Creation Date

  • December 1, 2013

Added to The UNT Digital Library

  • May 7, 2014, 12:22 a.m.

Description Last Updated

  • April 1, 2015, 3:59 p.m.

Usage Statistics

When was this article last used?

Yesterday: 0
Past 30 days: 1
Total Uses: 488

Interact With This Article

Here are some suggestions for what to do next.

Start Reading

PDF Version Also Available for Download.

International Image Interoperability Framework

IIF Logo

We support the IIIF Presentation API

Shrimali, Deepti; Shanmugam, Muthu K.; Kumar, Alan Prem; Zhang, Jingwen; Tan, Benny K-H; Ahn, Kwang Seok et al. Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer, article, December 1, 2013; [New York, New York]. (digital.library.unt.edu/ark:/67531/metadc284572/: accessed June 24, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.