Secreted Frizzled Related Proteins: Implications in Cancers Page: 2
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Abstract
The Wnt (wingless-type) signalling pathway plays an important role in embryonic
development, tissue homeostasis, and tumour progression because of its effect on cell proliferation,
migration, and differentiation. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors
of Wnt signalling that act by binding directly to Wnt ligands or to Frizzled receptors. In recent years,
aberrant expression of SFRPs has been reported to be associated with numerous cancers. As gene
expression of SFRP members is often lost through promoter hypermethylation, inhibition of
methylation through the use of epigenetic modifying agents could renew the expression of SFRP
members and further antagonize deleterious Wnt signalling. Several reports have described epigenetic
silencing of these Wnt signalling antagonists in various human cancers, suggesting their possible role
as tumour suppressors. SFRP family members thus come across as potential tools in combating Wnt-
driven tumourigenesis. However, little is known about SFRP family members and their role in
different cancers. This review comprehensively covers all the available information on the role of
SFRP molecules in various human cancers.ACCPTD ANSCIP
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Surana, Rohit; Sikka, Sakshi; Cai, Wanpei; Shin, Eun Myoung; Warrier, Sudha R.; Tan, Hong Jie Gabriel et al. Secreted Frizzled Related Proteins: Implications in Cancers, article, November 30, 2013; [New York, New York]. (https://digital.library.unt.edu/ark:/67531/metadc283650/m1/3/: accessed March 28, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Arts and Sciences.