Secreted Frizzled Related Proteins: Implications in Cancers

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Article on secreted frizzled related proteins and implications in cancers.

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41 p.

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Surana, Rohit; Sikka, Sakshi; Cai, Wanpei; Shin, Eun Myoung; Warrier, Sudha R.; Tan, Hong Jie Gabriel et al. November 30, 2013.

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Article on secreted frizzled related proteins and implications in cancers.

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41 p.

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Abstract: The Wnt (wingless-type) signalling pathway plays an important role in embryonic development, tissue homeostasis, and tumour progression because of its effect on cell proliferation, migration, and differentiation. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signalling that act by binding directly to Wnt ligands or to Frizzled receptors. In recent years, aberrant expression of SFRPs has been reported to be associated with numerous cancers. As gene expression of SFRP members is often lost through promoter hypermethylation, inhibition of methylation through the use of epigenetic modifying agents could renew the expression of SFRP members and further antagonize deleterious WNT signalling. Several reports have described epigenetic silencing of these Wnt signalling antagonists in various human cancers, suggesting their possible role as tumour suppressors. SFRP family members thus come across as potential tools in combating Wnt-driven tumourigenesis. However, little is known about SFRP family members and their role in different cancers. This review comprehensively covers all the available information on the role of SFRP molecules in various human cancers.

This is the accepted manuscript version of the article. Reprinted with permission from Elsevier Science Ltd, all rights reserved. The final definitive version is available here: http://dx.doi.org/10.1016/j.bbcan.2013.11.004

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  • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014, New York: Elsevier Science Ltd., pp. 53-65

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  • Publication Title: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  • Volume: 1845
  • Issue: 1
  • Page Start: 53
  • Page End: 65
  • Peer Reviewed: Yes

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  • November 30, 2013

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  • April 18, 2014, 5:08 a.m.

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  • April 1, 2015, 3:27 p.m.

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Surana, Rohit; Sikka, Sakshi; Cai, Wanpei; Shin, Eun Myoung; Warrier, Sudha R.; Tan, Hong Jie Gabriel et al. Secreted Frizzled Related Proteins: Implications in Cancers, article, November 30, 2013; [New York, New York]. (digital.library.unt.edu/ark:/67531/metadc283650/: accessed April 25, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.