Targeting PPARγ Signaling Cascade for the Prevention and Treatment of Prostate Cancer

PDF Version Also Available for Download.

Description

Article on targeting PPARy signaling cascade for the prevention and treatment of prostate cancer.

Physical Description

14 p.

Creation Information

Sikka, Sakshi; Chen, Luxi; Sethi, Gautam & Kumar, Alan Prem 2012.

Context

This article is part of the collection entitled: UNT Scholarly Works and was provided by UNT College of Arts and Sciences to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 61 times . More information about this article can be viewed below.

Who

People and organizations associated with either the creation of this article or its content.

Authors

  • Sikka, Sakshi National University of Singapore
  • Chen, Luxi National University of Singapore; Cancer Science Institute
  • Sethi, Gautam National University of Singapore; Cancer Science Institute
  • Kumar, Alan Prem University of North Texas; National University of Singapore; Cancer Science Institute; Curtin University

Publisher

Provided By

UNT College of Arts and Sciences

The UNT College of Arts and Sciences educates students in traditional liberal arts, performing arts, sciences, professional, and technical academic programs. In addition to its departments, the college includes academic centers, institutes, programs, and offices providing diverse courses of study.

Contact Us

What

Descriptive information to help identify this article. Follow the links below to find similar items on the Digital Library.

Degree Information

Description

Article on targeting PPARy signaling cascade for the prevention and treatment of prostate cancer.

Physical Description

14 p.

Notes

Abstract: The peroxisome proliferator-activated receptor-gamma (PPARγ) is a member of the hormone-activated nuclear receptor superfamily. PPARγ can be activated by a diverse group of agents, such as endogenous polyunsaturated fatty acids, 15-deoxy-Δ¹²'¹⁴-prostaglandin J₂ (15d-PGJ₂), and thiazolidinedione (TZD) drugs. PPARγ induces antiproliferative, antiangiogenic, and prodifferentiation pathways in several tissue types, thus making it a highly useful target for downregulation of carcinogenesis. The TZD-derived novel therapeutic agents, alone or in combination with other anticancer drugs, have translational relevance in fostering effective strategies for cancer treatment. TZDs have been proven for antitumor activity in a wide variety of experimental cancer models, both in vitro and in vivo, by affecting the cell cycle, inducing cell differentiation and apoptosis, as well as by inhibiting tumor angiogenesis. Angiogenesis inhibition mechanisms of TZDs include direct inhibition of endothelial cell proliferation and migration, as well as reduction in tumor cell vascular endothelial growth factor production. In prostate cancer, PPARγ ligands such as troglitazone and 15d-PGJ₂ have also shown to inhibit tumor growth. This paper will focus on current discoveries in PPARγ activation, targeting prostate carcinogenesis as well as the role of PPARγ as a possible anticancer therapeutic option. Here, we review PPARγ as an antitumor agent and summarize the antineoplastic effects of PPARγ agonists in prostate cancer.

Source

  • PPAR Research, 2012, Nasr City: Hindawi Publishing Corporation

Language

Item Type

Identifier

Unique identifying numbers for this article in the Digital Library or other systems.

Publication Information

  • Publication Title: PPAR Research
  • Volume: 2012
  • Pages: 14
  • Peer Reviewed: Yes

Collections

This article is part of the following collection of related materials.

UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

What responsibilities do I have when using this article?

When

Dates and time periods associated with this article.

Creation Date

  • 2012

Added to The UNT Digital Library

  • April 18, 2014, 5:08 a.m.

Usage Statistics

When was this article last used?

Yesterday: 0
Past 30 days: 0
Total Uses: 61

Interact With This Article

Here are some suggestions for what to do next.

Start Reading

PDF Version Also Available for Download.

International Image Interoperability Framework

IIF Logo

We support the IIIF Presentation API

Sikka, Sakshi; Chen, Luxi; Sethi, Gautam & Kumar, Alan Prem. Targeting PPARγ Signaling Cascade for the Prevention and Treatment of Prostate Cancer, article, 2012; [Nasr City, Cairo]. (digital.library.unt.edu/ark:/67531/metadc283649/: accessed July 16, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.