Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment

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Article on brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment.

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7 p.: ill.

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Wang, Jun; Ferruzzi, Mario G.; Ho, Lap; Blount, Jack W.; Janle, Elsa M.; Gong, Bing et al. April 11, 2012.

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Article on brain-targeted proanthocyanidin metabolites for Alzheimer's disease treatment.

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7 p.: ill.

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Abstract: While polyphenolic compounds have many health benefits, the potential development of polyphenols for the prevention/treatment of neurological disorders is largely hindered by their complexity as well as by limited knowledge regarding their bioavailability, metabolism, and bioactivity, especially in the brain. We recently demonstrated that dietary supplementation with a specific grape-derived polyphenolic preparation (GP) significantly improves cognitive function in a mouse model of Alzheimer's disease (AD). GP is compromised of the proanthocyanidin (PAC) catechin and epicatechin in monomeric (Mo), oligomeric, and polymeric forms. In this study, we report that following oral administration of the independent GP forms, only Mo is able to improve cognitive function and only Mo metabolites can selectively reach and accumulate in the brain at a concentration of ~400 nm. Most importantly, we report for the first time that a biosynthetic epicatechin metabolite, 3'-0-methyl-epicatechin-5-0-β-glucuronide (3'-0-Me-EC-Gluc), one of the PAC metabolites identified in the brain following Mo treatment, promotes basal synaptic transmission and long-term potentiation at physiologically relevant concentrations in hippocampus slices through mechanisms associated with cAMP response element binding protein (CREB) signaling. Our studies suggest that select brain-targeted PAC metabolites benefit cognition by improving synaptic plasticity in the brain, and provide impetus to develop 3'-0-Me-EC-Gluc and other brain-targeted PAC metabolites to promote learning and memory in AD and other forms of dementia.

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  • Journal of Neuroscience, 2012, Washington DC: Society for Neuroscience, pp. 5144-5150

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  • Publication Title: Journal of Neuroscience
  • Volume: 32
  • Issue: 15
  • Page Start: 5144
  • Page End: 5150
  • Peer Reviewed: Yes

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UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

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  • April 11, 2012

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  • March 31, 2014, 8:53 a.m.

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  • Jan. 6, 2015, 10:42 a.m.

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Wang, Jun; Ferruzzi, Mario G.; Ho, Lap; Blount, Jack W.; Janle, Elsa M.; Gong, Bing et al. Brain-Targeted Proanthocyanidin Metabolites for Alzheimer's Disease Treatment, article, April 11, 2012; [Washington, DC]. (digital.library.unt.edu/ark:/67531/metadc279694/: accessed September 20, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.