Depression and Heart Rate Variability in Patients with Coronary Artery Disease Page: 3
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Saunders, Roger D., Depression and Heart Rate
Variability in Patients with Coronary Artery Disease.
Doctor of Philosophy (Clinical Psychology), May, 1995, 81
pp., 8 tables, references, 114 titles.
Depression is an independent risk factor for morbidity
and mortality in patients with coronary artery disease
(CAD). Altered autonomic nervous system (ANS) activity, a
common feature of depression, is also a risk factor for
cardiac events in patients with CAD. Heart rate variability
(HRV) reflects ANS activity, and reduced HRV predicts
morbidity in cardiac populations. The purpose of this study
was to determine whether differences in HRV exist between
depressed and nondepressed patients with CAD. Twenty-one
depressed inpatients, with angiographically documented CAD
were retrospectively matched to 21 nondepressed CAD patients
by sex, age, and smoking status. Demographic, medical,
psychological interview data, and 24-hour ECG recordings
were obtained. Depressed subjects had significantly lower
HRV, or trends toward lower HRV, than nondepressed subjects,
even after controlling for severity of CAD. Subject groups
did not differ on left ventricular ejection fraction,
history of myocardial infarction, or any other relevant
medical variable assessed. These results suggest that
depression is associated with decreased HRV in patients with
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Saunders, Roger D. (Roger Dean). Depression and Heart Rate Variability in Patients with Coronary Artery Disease, dissertation, December 1994; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc278101/m1/3/: accessed September 20, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .