Physiological Effects of Ascaris Suum Intestinal Microflora on 5-Hydroxytryptamine Level and Binding Sites in the Intestinal Epithelial Cells Page: 4
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eliminated. The 5-HT turnover rates significantly increased
reaching the highest rate in intestine of worms incubated in
A. suum saline plus antibiotics for 48 hrs (301 ng 5-HT/mg
protein/hr). However, antibiotic treated intestinal tissue
showed an increase of more than 4 fold in its 5-HT turnover
rate which indicated that the elimination of 5-HT producing
bacteria stimulated the intestinal tissue to increase its
Serotonin receptor binding studies of the intestinal
tissue showed that elimination of intestinal microflora had
an effect on binding affinities and the apparent binding
densities. The [3H]-LSD binding sites increased in both
affinity and number in an anterior to posterior direction.
This directionality was altered when the intestinal
microflora were reduced.
Further characterization of 5-HT binding sites in
intestinal tissue indicated the presence of a specific
binding site in the intestinal membrane of A. suum.
L-tryptophan could possibly be transported across the
intestinal membrane independent of any 5-HT molecules
competing for the same site. However, L-tryptophan was found
to be capable of competing for [3H]-5-HT binding sites.
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Shahkolahi, Akbar Mohammadpour. Physiological Effects of Ascaris Suum Intestinal Microflora on 5-Hydroxytryptamine Level and Binding Sites in the Intestinal Epithelial Cells, dissertation, December 1991; Denton, Texas. (digital.library.unt.edu/ark:/67531/metadc277786/m1/4/: accessed October 19, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; .