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Article on interdisciplinary collaboration in hospice team meetings.
Physical Description
12 p.
Notes
This is the authors manuscript version of the article. Reprinted from the Journal of Interprofessional Care, 2010, 24:3, pp. 264-273. Reprinted with permission from Informa Healthcare. The final definitive version is available here: http://informahealthcare.com/doi/abs/10.3109/13561820903163421
Abstract: Cooperative activation of the thin filament is known to be influenced by the tight binding of myosin to actin, but the molecular mechanism underlying this contribution of myosin is not well understood. To better understand the structural relationship of myosin with the regulatory troponin complex, resonance energy transfer measurements were used to map the location of troponin relative to a neighboring myosin bound to actin using atomic models. Using a chicken troponin T isoform that contains a single cysteine near the binding interface between troponins T, I, and C, this uniquely labeled cysteine on troponin was found to be remarkably near loop 3 of myosin. This loop has previously been localized near the actin and myosin interface by chemical cross-linking methods, but its functional contributions have not been established. The implications of this close proximity are examined by molecular modeling, which suggests that only restricted conformations of actomyosin can accommodate the presence of troponin at this location near the cross-bridge. This potential for interaction between troponin and myosin heads that bind near it along the thin filament raises the possibility of models in which direct myosin and troponin interactions may play a role in the regulatory mechanism.
Publication Title:
Journal of Interprofessional Care
Volume:
24
Issue:
3
Page Start:
264
Page End:
273
Peer Reviewed:
Yes
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Wittenberg-Lyles, Elaine; Oliver, Debra Parker; Demiris, George & Regehr, Kelly A.Interdisciplinary Collaboration in Hospice Team Meetings,
article,
May 2010;
[London, United Kingdom].
(https://digital.library.unt.edu/ark:/67531/metadc277176/:
accessed December 2, 2023),
University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu;
crediting UNT College of Arts and Sciences.
