Solubility of Carvedilol in Ethanol + Propylene Glycol Mixtures at Various Temperatures

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Article on the solubility of carvedilol in ethanol and propylene glycol mixtures at various temperatures.

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7 p.

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Vahdati, Sahel; Shayanfar, Ali; Hanaee, Jalal; Martínez, Fleming; Acree, William E. (William Eugene) & Jouyban, Abolghasem October 30, 2013.

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Article on the solubility of carvedilol in ethanol and propylene glycol mixtures at various temperatures.

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7 p.

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Reprinted with permission from the Industrial and Engineering Chemistry Research journal. Copyright 2013 American Chemical Society.

Abstract: Solubilities of carvedilol (CVD) in binary mixtures of (ethanol + propylene glycol (PG)) at 298.2, 303.2, 308.2, and 313.2 K are reported. The modified versions of the van’t Hoff and Gibbs equations were used to calculate the thermodynamic properties (enthalpy (ΔH°), entropy (ΔS°), and Gibbs energy (ΔG°) standard changes of solutions) for CVD dissolved in (ethanol (1) + PG (2)) mixtures from the solubility data. The solubility data of CVD in (ethanol (1) + PG (2)) at different temperatures were correlated using different mathematical models, i.e., the Jouyban–Acree model, a combination of the Jouyban–Acree model with the van’t Hoff model, and two modified versions of the Jouyban–Acree model. Solubility data of seven drugs in (ethanol (1) + PG (2)) at different temperatures were used to develop a quantitative structure–property relationship model for predicting solubility in solvent mixtures. In addition, enthalpy–entropy compensation using ΔH° vs ΔG° and ΔH° vs TΔS° which explains the mechanism of cosolvency at different temperatures was discussed.

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  • Industrial and Engineering Chemistry Research, 2013, Washington D.C.: American Chemical Society, pp. 16630-16636

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  • Publication Title: Industrial and Engineering Chemistry Research
  • Volume: 52
  • Issue: 47
  • Page Start: 16630
  • Page End: 16636
  • Peer Reviewed: Yes

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  • October 30, 2013

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  • Dec. 20, 2013, 9:50 a.m.

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  • Feb. 10, 2015, 3:20 p.m.

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Vahdati, Sahel; Shayanfar, Ali; Hanaee, Jalal; Martínez, Fleming; Acree, William E. (William Eugene) & Jouyban, Abolghasem. Solubility of Carvedilol in Ethanol + Propylene Glycol Mixtures at Various Temperatures, article, October 30, 2013; [Washington, D.C.]. (digital.library.unt.edu/ark:/67531/metadc268932/: accessed November 17, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.