Photocaged DNA Methods for Biomimetic Materials

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The ability to replicate and manipulate the cellular microenvironment in vitro is essential for advancing our understanding of cell behavior, disease progression, and tissue regeneration. Traditional two-dimensional culture systems lack the spatial and mechanical complexity of native tissues, limiting their physiological relevance. To address these limitations, I developed engineered platforms that offer precise control over substrate stiffness, geometry, and cell organization. My goal was to create biomimetic systems that better recapitulate key features of the extracellular matrix and tissue architecture, enabling more predictive and informative in vitro studies. By leveraging recent advances in material science, light-based fabrication, and microscale patterning, … continued below

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Banks, Katelyn Meredith July 2025.

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This dissertation is part of the collection entitled: UNT Theses and Dissertations and was provided by the UNT Libraries to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 12 times. More information about this dissertation can be viewed below.

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  • Banks, Katelyn Meredith

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The ability to replicate and manipulate the cellular microenvironment in vitro is essential for advancing our understanding of cell behavior, disease progression, and tissue regeneration. Traditional two-dimensional culture systems lack the spatial and mechanical complexity of native tissues, limiting their physiological relevance. To address these limitations, I developed engineered platforms that offer precise control over substrate stiffness, geometry, and cell organization. My goal was to create biomimetic systems that better recapitulate key features of the extracellular matrix and tissue architecture, enabling more predictive and informative in vitro studies. By leveraging recent advances in material science, light-based fabrication, and microscale patterning, I was able to construct tunable environments that support both spatial and mechanical control. These systems allowed me to investigate how cells respond to localized cues, including stiffness changes and spatially patterned biochemical signals. I also incorporated automation into my fabrication workflows, enabling high-throughput experimentation with improved reproducibility and scalability. Through this work, I aimed to build physiologically relevant platforms that provide new opportunities for studying complex cell behaviors in controlled and customizable settings.

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  • July 2025

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  • Sept. 8, 2025, 8:45 p.m.

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  • Oct. 15, 2025, 12:56 p.m.

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Banks, Katelyn Meredith. Photocaged DNA Methods for Biomimetic Materials, dissertation, July 2025; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc2482628/: accessed June 12, 2026), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; .

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