Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles

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Article uses acid-resistant metal-organic framework nanoparticles (UiO-68-NH2) to encapsulate sufficient insulin and decorated the exterior with targeting proteins (transferrin) to realize highly efficient oral insulin delivery.

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12 p.

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Zou, Jun-Jie; Wei, Gaohui; Xiong, Chuxiao; Yu, Yunhao; Li, Sihui; Hu, Liefeng et al. February 23, 2022.

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Article uses acid-resistant metal-organic framework nanoparticles (UiO-68-NH2) to encapsulate sufficient insulin and decorated the exterior with targeting proteins (transferrin) to realize highly efficient oral insulin delivery.

Physical Description

12 p.

Notes

Abstract: Oral protein delivery is considered a cutting-edge technology to improve patients’ quality of life, offering superior patient compliance and convenience compared with injections. However, oral protein formulation has stagnated because of the instability and inefficient penetration of protein in the gastrointestinal tract. Here, we used acid-resistant metal-organic framework nanoparticles (UiO-68-NH2) to encapsulate sufficient insulin and decorated the exterior with targeting proteins (transferrin) to realize highly efficient oral insulin delivery. The UiO-68-NH2 nanocarrier with proper pore size achieved high insulin loading while protecting insulin from acid and enzymatic degradation. Through receptor-mediated transcellular pathway, the transferrin-coated nanoparticles realized efficient transport across the intestinal epithelium and controlled insulin release under physiological conditions, leading to a notable hypoglycemic effect and a high oral bioavailability of 29.6%. Our work demonstrates that functional metal-organic framework nanoparticles can protect proteins from the gastric environment and overcome the intestinal barrier, thus providing the possibility for oral biomacromolecule delivery.

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  • Science Advances, 8(8), American Association for the Advancement of Science, February 23 2022

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Publication Information

  • Publication Title: Science Advances
  • Volume: 8
  • Issue: 8
  • Article Identifier: eabm4677
  • Pages: 12
  • Peer Reviewed: Yes

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UNT Scholarly Works

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Submitted Date

  • September 20, 2021

Accepted Date

  • December 29, 2021

Creation Date

  • February 23, 2022

Added to The UNT Digital Library

  • June 29, 2022, 7:32 p.m.

Description Last Updated

  • Nov. 1, 2022, 9:54 a.m.

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Zou, Jun-Jie; Wei, Gaohui; Xiong, Chuxiao; Yu, Yunhao; Li, Sihui; Hu, Liefeng et al. Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles, article, February 23, 2022; (https://digital.library.unt.edu/ark:/67531/metadc1954019/: accessed April 18, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Science.

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