Collaborative Research: Using Uncertainty Quantification and Validated Computational Models to Analyze Pumping Performance of Valveless, Tubular Hearts

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Data management plan for the research grant, "Collaborative Research: Using Uncertainty Quantification and Validated Computational Models to Analyze Pumping Performance of Valveless, Tubular Hearts." This project will develop a computational model of the essential features of the circulatory system: the electrical activity of the heart, muscle contractions of the tube walls, and the fluid-structure interactions of the heart walls and blood within. This computational framework aims to be faithful to that of a real, model animal (tunicate, or sea squirt). The model will then be analyzed with mathematical tools to determine the physical limits of the pumping system. Results of … continued below

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He, Yanyan & Cain, John 2022-05-01/2025-04-30.

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  • He, Yanyan Principal Investigator, University of North Texas
  • Cain, John Co-Principal Investigator, Harvard University

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Data management plan for the research grant, "Collaborative Research: Using Uncertainty Quantification and Validated Computational Models to Analyze Pumping Performance of Valveless, Tubular Hearts." This project will develop a computational model of the essential features of the circulatory system: the electrical activity of the heart, muscle contractions of the tube walls, and the fluid-structure interactions of the heart walls and blood within. This computational framework aims to be faithful to that of a real, model animal (tunicate, or sea squirt). The model will then be analyzed with mathematical tools to determine the physical limits of the pumping system. Results of this project will improve the understanding of human heart development at the earliest stages. Also, it will point to how the large, multi-chambered hearts of vertebrates could have evolved from smaller structures.

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UNT Funded Research Projects

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  • 2022-05-01/2025-04-30

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  • March 21, 2022, 1:49 p.m.

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  • April 14, 2022, 11:12 a.m.

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PDF Version Also Available for Download.

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He, Yanyan & Cain, John. Collaborative Research: Using Uncertainty Quantification and Validated Computational Models to Analyze Pumping Performance of Valveless, Tubular Hearts, text, 2022-05-01/2025-04-30; (https://digital.library.unt.edu/ark:/67531/metadc1916230/: accessed March 25, 2023), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Science.

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