Effects of Surface Texture and Porosity on the Corrosion Behavior and Biocompatibility of Pure Zinc Biomaterials for Orthopedic Applications

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In this dissertation, small and large NaCl particle-derived surfaces (Ra > 40 microns) were generated on 2D Zn materials, and the surfaces were carefully studied concerning topography, corrosion behavior, and bone cell compatibility. Increases in surface roughness accelerated the corrosion rate, and cell viability was maintained. This method was then extended to 3D porous scaffolds prepared by a hybrid AM/casting technique. The scaffolds displayed a near-net shape, an interconnected pore structure, increasing porosity paralleled to an increased corrosion rate, an ability to support cell growth, and powerful antibacterial properties. Lastly, nano/micro (Rz 0.02–1 microns) topographies were generated on 2D Zn … continued below

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x, 125 pages

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Cockerill, Irsalan May 2021.

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  • Cockerill, Irsalan

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In this dissertation, small and large NaCl particle-derived surfaces (Ra > 40 microns) were generated on 2D Zn materials, and the surfaces were carefully studied concerning topography, corrosion behavior, and bone cell compatibility. Increases in surface roughness accelerated the corrosion rate, and cell viability was maintained. This method was then extended to 3D porous scaffolds prepared by a hybrid AM/casting technique. The scaffolds displayed a near-net shape, an interconnected pore structure, increasing porosity paralleled to an increased corrosion rate, an ability to support cell growth, and powerful antibacterial properties. Lastly, nano/micro (Rz 0.02–1 microns) topographies were generated on 2D Zn materials, and the materials were comprehensively studied with special attention devoted to corrosion behavior, biocompatibility, osteogenic differentiation, immune cell response, hemocompatibility, and antibacterial performance. For the first time, the textured nonhemolytic surfaces on Zn were shown to direct cell fate, and the micro-textures promoted bone cell differentiation and directed immune cells away from an inflammatory phenotype.

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x, 125 pages

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  • May 2021

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  • May 26, 2021, 9:04 p.m.

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  • Jan. 29, 2025, 11:42 a.m.

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Cockerill, Irsalan. Effects of Surface Texture and Porosity on the Corrosion Behavior and Biocompatibility of Pure Zinc Biomaterials for Orthopedic Applications, dissertation, May 2021; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc1808356/: accessed February 18, 2025), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; .

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