Chronic Hypoxia and Hyperoxia Modifies Morphology and Vegf Expression of the Lungs of the Developing Chicken (Gallus Gallus Domesticus) Metadata

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Title

  • Main Title Chronic Hypoxia and Hyperoxia Modifies Morphology and Vegf Expression of the Lungs of the Developing Chicken (Gallus Gallus Domesticus)

Creator

  • Author: Lewallen, Melissa Anjanette
    Creator Type: Personal

Contributor

  • Chair: Burggren, Warren W.
    Contributor Type: Personal
    Contributor Info: Major Professor
  • Committee Member: Dzialowski, Edward M. (Edward Michael)
    Contributor Type: Personal
  • Committee Member: Huggett, Duane
    Contributor Type: Personal

Publisher

  • Name: University of North Texas
    Place of Publication: Denton, Texas
    Additional Info: www.unt.edu

Date

  • Creation: 2012-12

Language

  • English

Description

  • Content Description: This study determines effects of oxygen levels on morphology and VEGF expression of developing chicken lungs following incubation in normoxia (21% O2), hypoxia (15% O2) or hyperoxia (30% O2), until developmental days 16 or 18. Lung morphology was assessed using light microscopy, while VEGF expression was determined with ELISA. In hypoxia, the proportion of parabronchial tissue and parabronchi including lumina increased from day 16 to 18 (61 to 68% and 74.2 to 82.2%, respectively). Non-parabronchial tissue was higher in hypoxia than in hyperoxia on day 16 (26 to 20%). However, by day 18, there were no differences between groups. VEGF expression was 33% higher in hypoxia than in hyperoxia on day 16 (736 vs. 492 pg/ml). On day 18, VEGF expression was 43% higher in hyperoxia than in normoxia (673 to 381pg/ml), and remained elevated by 40% in hypoxia over normoxia (631 pg/ml). VEGF may be a mechanism by which parabronchial tissue is stimulated from day 16 to 18 following exposure to chronic hypoxia.

Subject

  • Keyword: Lung development
  • Keyword: VEGF
  • Keyword: hypoxia
  • Keyword: hyperoxia
  • Keyword: oxygen

Collection

  • Name: UNT Theses and Dissertations
    Code: UNTETD

Institution

  • Name: UNT Libraries
    Code: UNT

Rights

  • Rights Access: public
  • Rights Holder: Lewallen, Melissa Anjanette
  • Rights License: copyright
  • Rights Statement: Copyright is held by the author, unless otherwise noted. All rights Reserved.

Resource Type

  • Thesis or Dissertation

Format

  • Text

Identifier

  • Archival Resource Key: ark:/67531/metadc177224

Degree

  • Academic Department: Department of Biological Sciences
  • Degree Discipline: Biology
  • Degree Level: Master's
  • Degree Name: Master of Science
  • Degree Grantor: University of North Texas
  • Degree Publication Type: thesi

Note