Solubility of 5-(2-Chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one, 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one, and 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine in the Mixtures of Poly(ethylene glycol) 600, Ethanol, and Water at a Temperature of 298.2 K

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Article on the solubility of 5-(2-chlorophenyl)-7-nitro-1, 3-dihydro-1, 4-benzodiazepin-2-one, 7-chloro-1-methyl-5-phenyl-3H-1, 4-benzodiazepin-2-one, and 6-(2,3-dichlorophenyl)-1, 2, 4,-triazine-3, 5-diamine in the mixtures of poly(ethylene glycol) 600, ethanol, and water at temperature of 298.2 K.

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5 p.

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Soltanpour, Shahla; Acree, William E. (William Eugene) & Jouyban, Abolghasem October 23, 2009.

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Article on the solubility of 5-(2-chlorophenyl)-7-nitro-1, 3-dihydro-1, 4-benzodiazepin-2-one, 7-chloro-1-methyl-5-phenyl-3H-1, 4-benzodiazepin-2-one, and 6-(2,3-dichlorophenyl)-1, 2, 4,-triazine-3, 5-diamine in the mixtures of poly(ethylene glycol) 600, ethanol, and water at temperature of 298.2 K.

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5 p.

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Reprinted with permission from the Journal of Chemical and Engineering Data. Copyright 2009 American Chemical Society.

Abstract: Experimental solubilities of 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one (clonazepam), 7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one (diazepam), and 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine (lamotrigine) in poly(ethylene glycol) (PEG) 600 (1) + ethanol (2), PEG 600 (1) + water (3), and PEG 600 (1) + ethanol (2) + water (3) mixtures at T = 298.2 K are reported. The Jouyban−Acree model was used to fit the solubility data of each drug in the ternary and sub-binary solvent mixtures in which the mean deviations for clonazepam, diazepam, and lamotrigine were 6.1%, 8.3%, and 10.9%, respectively, and the overall value was 8.4%.

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  • Journal of Chemical and Engineering Data, 2009, Washington D.C.: American Chemical Society, pp. 1727-1731

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  • Publication Title: Journal of Chemical and Engineering Data
  • Volume: 55
  • Issue: 4
  • Page Start: 1727
  • Page End: 1731
  • Peer Reviewed: Yes

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  • October 23, 2009

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  • June 28, 2013, 2:11 p.m.

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Soltanpour, Shahla; Acree, William E. (William Eugene) & Jouyban, Abolghasem. Solubility of 5-(2-Chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one, 7-Chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one, and 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine in the Mixtures of Poly(ethylene glycol) 600, Ethanol, and Water at a Temperature of 298.2 K, article, October 23, 2009; [Washington, D.C.]. (digital.library.unt.edu/ark:/67531/metadc172355/: accessed July 22, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.