Solubility of Budesonide, Hydrocortisone, and Prednisolone in Ethanol + Water Mixtures at 298.2 K

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This article discusses the solubility of budesonide, hydrocortisone, and prednisolone in ethanol and water mixtures at 298.2 K.

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5 p.

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Ali, Hany Saleh Mohamed; Blagden, Nicholas; York, Peter; Soltanpour, Shahla; Acree, William E. (William Eugene) & Jouyban, Abolghasem September 14, 2009.

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This article discusses the solubility of budesonide, hydrocortisone, and prednisolone in ethanol and water mixtures at 298.2 K.

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5 p.

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Reprinted with permission from the Journal of Chemical and Engineering Data. Copyright 2009 American Chemical Society.

Abstract: Experimental solubilities of budesonide, hydrocortisone, and prednisolone in ethanol + water mixtures at 298.2 K are reported. The solubility of drugs was increased with the addition of ethanol and reached the maximum values of the volume fractions of 90%, 80%, and 80% of ethanol. The Jouyban−Acree model was used to fit the experimental data, and the solubilities were reproduced using previously trained versions of the Jouyban−Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 5.1%, 6.4%, 37.7%, and 35.9%, respectively, for the fitted model, the trained version for ethanol + water mixtures, and generally trained versions for various organic solvents + water mixtures. Solubilities were also predicted by a previously established log−linear model of Yalkowsky with the OMRD of 53.8%.

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  • Journal of Chemical and Engineering Data, 2009, Washington D.C.: American Chemical Society, pp. 578-582

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  • Publication Title: Journal of Chemical and Engineering Data
  • Volume: 55
  • Issue: 1
  • Page Start: 578
  • Page End: 582
  • Peer Reviewed: Yes

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  • September 14, 2009

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  • June 28, 2013, 2:11 p.m.

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  • Jan. 9, 2015, 4:04 p.m.

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Ali, Hany Saleh Mohamed; Blagden, Nicholas; York, Peter; Soltanpour, Shahla; Acree, William E. (William Eugene) & Jouyban, Abolghasem. Solubility of Budesonide, Hydrocortisone, and Prednisolone in Ethanol + Water Mixtures at 298.2 K, article, September 14, 2009; [Washington, D.C.]. (digital.library.unt.edu/ark:/67531/metadc172354/: accessed April 21, 2018), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.