Solubility of 7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4-oxide, 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, and 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one in (Propane-1,2-diol + Water) at a Temperature of 303.2 K Metadata

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Title

  • Main Title Solubility of 7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4-oxide, 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, and 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one in (Propane-1,2-diol + Water) at a Temperature of 303.2 K

Creator

  • Author: Jouyban, Abolghasem
    Creator Type: Personal
    Creator Info: Tabriz University of Medical Sciences
  • Author: Shokri, Javad
    Creator Type: Personal
    Creator Info: Tabriz University of Medical Sciences
  • Author: Barzegar-Jalali, Mohammad
    Creator Type: Personal
    Creator Info: Tabriz University of Medical Sciences
  • Author: Hassanzadeh, Davoud
    Creator Type: Personal
    Creator Info: Tabriz University of Medical Sciences
  • Author: Acree, William E. (William Eugene)
    Creator Type: Personal
    Creator Info: University of North Texas
  • Author: Ghafourian, Taravat
    Creator Type: Personal
    Creator Info: Universities of Kent and Greenwich
  • Author: Nokhodchi, Ali
    Creator Type: Personal
    Creator Info: Universities of Kent and Greenwich

Publisher

  • Name: American Chemical Society
    Place of Publication: [Washington, D.C.]

Date

  • Creation: 2009-07-31

Language

  • English

Description

  • Content Description: Article on 7-chloro-2-methylamino-5-phenyl-3H-1, 4-benzodiazepine-4-oxide, 7-chloro-1, 3-dihydro-1-methyl-5-phenyl-2H-1, 4-benzodiazepin-2-one, and 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1, 3-dihydro-1, 4-benzodiazepin-2-one in (propane-1, 2-diol + water) at a temperature of 303.2 K.
  • Physical Description: 4 p.

Subject

  • Keyword: solubility data
  • Keyword: binary solvent mixtures
  • Keyword: Jouyban-Acree model

Source

  • Journal: Journal of Chemical and Engineering Data, 2009, Washington D.C.: American Chemical Society, pp. 539-542

Citation

  • Publication Title: Journal of Chemical and Engineering Data
  • Volume: 55
  • Issue: 1
  • Page Start: 539
  • Page End: 542
  • Peer Reviewed: True

Collection

  • Name: UNT Scholarly Works
    Code: UNTSW

Institution

  • Name: UNT College of Arts and Sciences
    Code: UNTCAS

Rights

  • Rights Access: public

Resource Type

  • Article

Format

  • Text

Identifier

  • DOI: 10.1021/je900451d
  • Archival Resource Key: ark:/67531/metadc172351

Degree

  • Academic Department: Chemistry

Note

  • Display Note: Reprinted with permission from the Journal of Chemical and Engineering Data. Copyright 2009 American Chemical Society.
  • Display Note: Abstract: Experimental solubilities of 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4-oxide (chlordiazepoxide), 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one (diazepam), and 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one (lorazepam) in (propane-1,2-diol + water) at T = 303.2 K were reported. The solubility of drugs increased with the addition of propane-1,2-diol and reached the maximum values in pure propane-1,2-diol. The Jouyban−Acree model was used to fit the experimental data, and the solubilities were reproduced using a previously trained version of the Jouyban−Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the back-calculated and predicted values with the corresponding experimental data were 4.2% and 10.7%. The solubilities of the three drugs were also predicted using a trained version of the log−linear model of Yalkowsky, and the OMRD was 21.1%.