Solubility of 7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4-oxide, 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, and 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one in (Propane-1,2-diol + Water) at a Temperature of 303.2 K

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Article on 7-chloro-2-methylamino-5-phenyl-3H-1, 4-benzodiazepine-4-oxide, 7-chloro-1, 3-dihydro-1-methyl-5-phenyl-2H-1, 4-benzodiazepin-2-one, and 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1, 3-dihydro-1, 4-benzodiazepin-2-one in (propane-1, 2-diol + water) at a temperature of 303.2 K.

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4 p.

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Jouyban, Abolghasem; Shokri, Javad; Barzegar-Jalali, Mohammad; Hassanzadeh, Davoud; Acree, William E. (William Eugene); Ghafourian, Taravat et al. July 31, 2009.

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Article on 7-chloro-2-methylamino-5-phenyl-3H-1, 4-benzodiazepine-4-oxide, 7-chloro-1, 3-dihydro-1-methyl-5-phenyl-2H-1, 4-benzodiazepin-2-one, and 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1, 3-dihydro-1, 4-benzodiazepin-2-one in (propane-1, 2-diol + water) at a temperature of 303.2 K.

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4 p.

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Reprinted with permission from the Journal of Chemical and Engineering Data. Copyright 2009 American Chemical Society.

Abstract: Experimental solubilities of 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4-oxide (chlordiazepoxide), 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one (diazepam), and 7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one (lorazepam) in (propane-1,2-diol + water) at T = 303.2 K were reported. The solubility of drugs increased with the addition of propane-1,2-diol and reached the maximum values in pure propane-1,2-diol. The Jouyban−Acree model was used to fit the experimental data, and the solubilities were reproduced using a previously trained version of the Jouyban−Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the back-calculated and predicted values with the corresponding experimental data were 4.2% and 10.7%. The solubilities of the three drugs were also predicted using a trained version of the log−linear model of Yalkowsky, and the OMRD was 21.1%.

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  • Journal of Chemical and Engineering Data, 2009, Washington D.C.: American Chemical Society, pp. 539-542

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  • Publication Title: Journal of Chemical and Engineering Data
  • Volume: 55
  • Issue: 1
  • Page Start: 539
  • Page End: 542
  • Peer Reviewed: Yes

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  • July 31, 2009

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  • June 28, 2013, 2:11 p.m.

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  • Jan. 9, 2015, 5:19 p.m.

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Jouyban, Abolghasem; Shokri, Javad; Barzegar-Jalali, Mohammad; Hassanzadeh, Davoud; Acree, William E. (William Eugene); Ghafourian, Taravat et al. Solubility of 7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4-oxide, 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, and 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one in (Propane-1,2-diol + Water) at a Temperature of 303.2 K, article, July 31, 2009; [Washington, D.C.]. (digital.library.unt.edu/ark:/67531/metadc172351/: accessed October 24, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.