Study of the fabrication of AISI 316L microneedle arrays

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Article describes a study in which a micro milling process was used to manufacture AISI 316L stainless steel needles arrays with a conical geometry (i.e., a base diameter and height of 1 mm by 1 mm, respectively), and an analysis of tool wear on ball nose micro end milling tools with a diameter of ~200 μm was performed to evaluate the use of lubricant in the manufacture of those conical surfaces.

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8 p.

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García-López, Erika; Siller Carrillo, Héctor Rafael & Rodríguez, Ciro A. August 3, 2018.

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This article is part of the collection entitled: UNT Scholarly Works and was provided by the UNT College of Engineering to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 65 times. More information about this article can be viewed below.

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Article describes a study in which a micro milling process was used to manufacture AISI 316L stainless steel needles arrays with a conical geometry (i.e., a base diameter and height of 1 mm by 1 mm, respectively), and an analysis of tool wear on ball nose micro end milling tools with a diameter of ~200 μm was performed to evaluate the use of lubricant in the manufacture of those conical surfaces.

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8 p.

Notes

Abstract: Microneedles are an alternative to deliver chemical compounds through the skin for the treatment of several health conditions. In this work, a micro milling process was used to manufacture AISI 316L stainless steel needles arrays with a conical geometry (i.e., a base diameter and height of 1 mm by 1 mm, respectively). An analysis of tool wear on ball nose micro end milling tools with a diameter of ~200 μm was performed to evaluate the use of lubricant in the manufacture of those conical surfaces. A tool diameter reduction of 6% and 8% was obtained in dry cutting and wet cutting, after the manufacture of 9 and 54 needles respectively. Geometrical features on the needle tip resulted more affected in dry cutting regime compared with the wet treatment. A maximum needle tip diameter of 188 μm was reported on dry cutting versus values lower than 30 μm using wet regime. The results indicate that surface roughness increases after machining 36 and 9 needles in wet cutting regime and dry cutting treatment, respectively. However tool breakage occurs after milling 12 needles in dry cutting. A cost analysis shows that the micro milling approach is a competitive method for prototyping of microneedle arrays.

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  • Procedia Manufacturing, 26, Elsevier Science Ltd., August 2018, p. 117-124

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  • Publication Title: Procedia Manufacturing
  • Volume: 26
  • Page Start: 117
  • Page End: 124
  • Peer Reviewed: Yes

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  • August 3, 2018

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  • Aug. 3, 2020, 3:07 p.m.

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  • Oct. 7, 2022, 2:53 p.m.

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García-López, Erika; Siller Carrillo, Héctor Rafael & Rodríguez, Ciro A. Study of the fabrication of AISI 316L microneedle arrays, article, August 3, 2018; (https://digital.library.unt.edu/ark:/67531/metadc1705509/: accessed February 23, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Engineering.

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