Magnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1, and S1P1

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Article discusses the role of Mg2+ in regulating vascular functions.

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13 p.

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Zhu, Donghui; You, Jing; Zhao, Nan & Xu, Huaxi July 30, 2019.

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Article discusses the role of Mg2+ in regulating vascular functions.

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13 p.

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Abstract: Mg2+‐deficiency is linked to hypertension, Alzheimer's disease, stroke, migraine headaches, cardiovascular diseases, and diabetes, etc., but its exact role in these pathophysiological conditions remains elusive. Mg2+ can regulate vascular functions, yet the mechanistic insight remains ill‐defined. Data show that extracellular Mg2+ enters endothelium mainly through the TRPM7 channel and MagT1 transporter. Mg2+ can act as an antagonist to reduce Ca2+ signaling in endothelium. Mg2+ also reduces the intracellular reactive oxygen species (ROS) level and inflammation. In addition, Mg2+‐signaling increases endothelial survival and growth, adhesion, and migration. Endothelial barrier integrity is significantly enhanced with Mg2+‐treatment through S1P1‐Rac1 pathways and barrier‐stabilizing mediators including cAMP, FGF1/2, and eNOS. Mg2+ also promotes cytoskeletal reorganization and junction proteins to tighten up the barrier. Moreover, Mg2+‐deficiency enhances endothelial barrier permeability in mice, and Mg2+‐treatment rescues histamine‐induced transient vessel hyper‐permeability in vivo. In summary, Mg2+‐deficiency can cause deleterious effects in endothelium integrity, and Mg2+‐treatment may be effective in the prevention or treatment of vascular dysfunction.

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  • Advanced Science, 6(18), John Wiley & Sons, July 30, 2019, pp. 1-13

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  • Publication Title: Advanced Science
  • Volume: 6
  • Issue: 18
  • Pages: 13
  • Peer Reviewed: Yes

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UNT Scholarly Works

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  • July 30, 2019

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  • June 16, 2020, 10:27 a.m.

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  • Nov. 14, 2023, 12:33 p.m.

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Zhu, Donghui; You, Jing; Zhao, Nan & Xu, Huaxi. Magnesium Regulates Endothelial Barrier Functions through TRPM7, MagT1, and S1P1, article, July 30, 2019; (https://digital.library.unt.edu/ark:/67531/metadc1703662/: accessed March 3, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Science.

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