Chemical Conditioning as an Approach to Ischemic Stroke Tolerance: Mitochondria as the Target

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This article focuses on chemical conditioning of mitochondrial proteins as targets for neuroprotection against ischemic stroke injury.

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13 p.

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Jin, Zhen; Wu, Jinzi & Yan, Liang-Jun March 8, 2016.

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  • Jin, Zhen University of North Texas Health Science Center
  • Wu, Jinzi University of North Texas Health Science Center
  • Yan, Liang-Jun University of North Texas Health Science Center

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UNT Health Science Center is one of the nation's premier graduate academic medical centers, with five schools that specialize in patient-centered education, research, and health care: Texas College of Osteopathic Medicine, Graduate School of Biomedical Sciences, School of Public Health, School of Health Professions, and UNT System College of Pharmacy.

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Description

This article focuses on chemical conditioning of mitochondrial proteins as targets for neuroprotection against ischemic stroke injury.

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13 p.

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Abstract: It is well established that the brain can be prepared to resist or tolerate ischemic stroke injury, and mitochondrion is a major target for this tolerance. The preparation of ischemic stroke tolerance can be achieved by three major approaches: ischemic conditioning, hypoxic conditioning and chemical conditioning. In each conditioning approach, there are often two strategies that can be used to achieve the conditioning effects, namely preconditioning (Pre-C) and postconditioning (Post-C). In this review, we focus on chemical conditioning of mitochondrial proteins as targets for neuroprotection against ischemic stroke injury. Mitochondrial targets covered include complexes I, II, IV, the ATP-sensitive potassium channel (mitoKATP), adenine dinucleotide translocase (ANT) and the mitochondrial permeability transition pore (mPTP). While numerous mitochondrial proteins have not been evaluated in the context of chemical conditioning and ischemic stroke tolerance, the paradigms and approaches reviewed in this article should provide general guidelines on testing those mitochondrial components that have not been investigated. A deep understanding of mitochondria as the target of chemical conditioning for ischemic stroke tolerance should provide valuable insights into strategies for fighting ischemic stroke, a leading cause of death in the world.

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  • International Journal of Molecular Sciences, 17(3), Multidisciplinary Digital Publishing Institute, March 2016

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  • Publication Title: International Journal of Molecular Sciences
  • Volume: 17
  • Issue: 3
  • Peer Reviewed: Yes

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UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

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  • March 8, 2016

Added to The UNT Digital Library

  • May 11, 2020, 3:41 p.m.

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  • May 26, 2020, 3:42 p.m.

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Jin, Zhen; Wu, Jinzi & Yan, Liang-Jun. Chemical Conditioning as an Approach to Ischemic Stroke Tolerance: Mitochondria as the Target, article, March 8, 2016; [Basel, Switzerland]. (https://digital.library.unt.edu/ark:/67531/metadc1638278/: accessed July 15, 2020), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Health Science Center.