The Emerging Roles of mTORC1 in Macromanaging Autophagy

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Review critically analyzes current literature to provide an integrated view of how rapamycin complex 1 (mTORC1) regulates various steps of the autophagy process.

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17 p.

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Dossou, Akpedje S. & Basu, Alakananda September 24, 2019.

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This article is part of the collection entitled: UNT Scholarly Works and was provided by the UNT Health Science Center to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 89 times, with 5 in the last month. More information about this article can be viewed below.

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Review critically analyzes current literature to provide an integrated view of how rapamycin complex 1 (mTORC1) regulates various steps of the autophagy process.

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17 p.

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Abstract: Autophagy is a process of self-degradation that enables the cell to survive when faced with starvation or stressful conditions. The mechanistic target of rapamycin (mTOR), also known as the mammalian target of rapamycin, plays a critical role in maintaining a balance between cellular anabolism and catabolism. mTOR complex 1 (mTORC1) was unveiled as a master regulator of autophagy since inhibition of mTORC1 was required to initiate the autophagy process. Evidence has emerged in recent years to indicate that mTORC1 also directly regulates the subsequent steps of the autophagy process, including the nucleation, autophagosome elongation, autophagosome maturation and termination. By phosphorylating select protein targets of the autophagy core machinery and/or their regulators, mTORC1 can alter their functions, increase their proteasomal degradation or modulate their acetylation status, which is a key switch of the autophagy process. Moreover, it phosphorylates and alters the subcellular localization of transcription factors to suppress the expression of genes needed for autophagosome formation and lysosome biogenesis. The purpose of this review article is to critically analyze current literatures to provide an integrated view of how mTORC1 regulates various steps of the autophagy process.

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  • Cancers, 11(10), MDPI, September 24, 2019, pp. 1-17

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  • Publication Title: Cancers
  • Volume: 11
  • Issue: 10
  • Pages: 17
  • Peer Reviewed: Yes

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UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

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  • September 24, 2019

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  • May 11, 2020, 3:41 p.m.

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  • Nov. 21, 2023, 10:30 a.m.

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Dossou, Akpedje S. & Basu, Alakananda. The Emerging Roles of mTORC1 in Macromanaging Autophagy, article, September 24, 2019; [Basel, Switzerland]. (https://digital.library.unt.edu/ark:/67531/metadc1638211/: accessed March 28, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Health Science Center.

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