Evaluation of the eSensor® XT-8 System for Determining CYP2C9 and VKORC1 Genotypes to Aid in Correct Warfarin Dosing

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Paper discusses the capabilities of the eSensor® XT-8, which is designed to assist doctors in determining the dose and effectiveness of warfarin in patients by detecting polymorphisms in the genes CYP2C9 and VKORC1.

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13 p.

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Kirk, Jason 2009.

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This article is part of the collection entitled: The Eagle Feather and was provided by the UNT Libraries to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 52 times. More information about this article can be viewed below.

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  • Hocker, Kimberly Scott & White Memorial Hospital Molecular Pathology Laboratory
  • Rao, Arundhati Scott & White Memorial Hospital Molecular Pathology Laboratory

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Paper discusses the capabilities of the eSensor® XT-8, which is designed to assist doctors in determining the dose and effectiveness of warfarin in patients by detecting polymorphisms in the genes CYP2C9 and VKORC1.

Physical Description

13 p.

Notes

Abstract: Warfarin is a commonly prescribed anticoagulant used to treat a variety of disorders; however it has a narrow therapeutic window and response varies widely among individuals. Addition of genetic information, especially for genes CYP2C9 and VKORC1, could potentially improve dosing algorithms. The eSensor® XT-8 is novel technology capable of detecting polymorphisms in these genes. CYP2C9 is the gene that codes for the enzyme that metabolizes warfarin into its inactive metabolites, and mutant *2 and *3 alleles decrease warfarin clearance. VKORC1 codes for an enzyme the recycles reduced vitamin K making it available for use by vitamin K-dependent coagulation factors, and the mutant A allele decreases action. The anticoagulant activity of warfarin is due to inhibition of the VKORC1 enzyme. The results of this study revealed that 47% of the 98 participants had the mutant A allele in the VKORC1 gene and 34% had the mutant *2 or *3 allele for CYP2C9. As a result, these individuals are likely more sensitive to the action of warfarin and/or less effective at clearing the drug. Genetic information could be helpful in determining warfarin dosage but is only one of many factors in warfarin dosing, including age, weight, height, and ethnicity. Validation of the eSensor® Warfarin Sensitivity Test is ongoing at Scott and White Memorial Hospital.

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  • Eagle Feather, Issue 6, University of North Texas Honors College: Denton, Texas. 2009

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  • Publication Title: Eagle Feather
  • Volume: 6
  • Issue: 2009
  • Peer Reviewed: Yes

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The Eagle Feather

Launched in 2004 by UNT's Honors College, The Eagle Feather was an interdisciplinary undergraduate research journal that promoted the work of students and their faculty mentors. The Eagle Feather was published annually until 2017 when it transitioned into the North Texas Journal of Undergraduate Research.

UNT Undergraduate Student Works

This collection presents scholarly and artistic content created by undergraduate students. All materials have been previously accepted by a professional organization or approved by a faculty mentor. Most classroom assignments are not eligible for inclusion. The collection includes, but is not limited to Honors College theses, thesis supplemental files, professional presentations, articles, and posters. Some items in this collection are restricted to use by the UNT community.

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  • 2009

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  • March 22, 2020, 10:07 a.m.

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  • April 15, 2020, 12:15 p.m.

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Kirk, Jason. Evaluation of the eSensor® XT-8 System for Determining CYP2C9 and VKORC1 Genotypes to Aid in Correct Warfarin Dosing, article, 2009; Denton, Texas. (https://digital.library.unt.edu/ark:/67531/metadc1633130/: accessed February 15, 2025), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; .

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