The Biological and Toxicological Activity of Gases and Vapors

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Article discussing research on the biological and toxicological activity of gases and vapors.

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15 p.

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Abraham, M. H. (Michael H.); Sánchez-Moreno, Ricardo; Gil-Lostes, Javier; Acree, William E. (William Eugene); Cometto-Muñiz, J. Enrique & Cain, William S. March 2010.

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Description

Article discussing research on the biological and toxicological activity of gases and vapors.

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15 p.

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This is the accepted manuscript version of the article. Reprinted with permission from Elsevier Science Ltd., all rights reserved. The final definitive version is available here: http://dx.doi.org/10.1016/j.tiv.2009.11.009

Abstract: A large amount of data on the biological and toxicological activity of gases and vapors has been collected from the literature. Processes include sensory irritation thresholds, the Alarie mouse test, inhalation anasthesia, etc. It is shown that a single equation using only five descriptors (properties of the gases and vapors) plus a set of indicator variables for the given processes can correlate 643 biological and non-lethal toxicological activities of 'non-reactive' compounds with a standard deviation of 0.36 log unit. The equation is scaled to sensory irritation thresholds obtained by the procedure of Cometto-Muñiz, and Cain, and provides a general equation for the prediction of sensory irritation thresholds in man. It is suggested that differences in biological/toxicological activity arise primarily from transport from the gas phase to a receptor phase or area, except for odor detection thresholds where interaction with a receptor(s) is important.

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  • Toxicology in Vitro, 2010, New York: Elsevier Science Ltd., pp. 357-362

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Publication Information

  • Publication Title: Toxicology in Vitro
  • Volume: 24
  • Issue: 2
  • Page Start: 357
  • Page End: 362
  • Peer Reviewed: Yes

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  • March 2010

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  • March 22, 2013, 6:09 p.m.

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  • April 1, 2015, 1:45 p.m.

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Abraham, M. H. (Michael H.); Sánchez-Moreno, Ricardo; Gil-Lostes, Javier; Acree, William E. (William Eugene); Cometto-Muñiz, J. Enrique & Cain, William S. The Biological and Toxicological Activity of Gases and Vapors, article, March 2010; [New York, New York]. (digital.library.unt.edu/ark:/67531/metadc152441/: accessed November 20, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.