Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications

PDF Version Also Available for Download.

Description

This review compares the advantages and disadvantages of decellularization methods in terms of their ability to retain desired extracellular matrix characteristics for particular tissues and organs.

Physical Description

13 p.

Creation Information

Gilpin, Anna & Yang, Yong April 30, 2017.

Context

This article is part of the collection entitled: UNT Scholarly Works and was provided by UNT College of Engineering to Digital Library, a digital repository hosted by the UNT Libraries. More information about this article can be viewed below.

Who

People and organizations associated with either the creation of this article or its content.

Authors

Publisher

Provided By

UNT College of Engineering

The UNT College of Engineering strives to educate and train engineers and technologists who have the vision to recognize and solve the problems of society. The college comprises six degree-granting departments of instruction and research.

Contact Us

What

Descriptive information to help identify this article. Follow the links below to find similar items on the Digital Library.

Degree Information

Description

This review compares the advantages and disadvantages of decellularization methods in terms of their ability to retain desired extracellular matrix characteristics for particular tissues and organs.

Physical Description

13 p.

Notes

Abstract: As the gap between donors and patients in need of an organ transplant continues to widen, research in regenerative medicine
seeks to provide alternative strategies for treatment. One of the most promising techniques for tissue and organ regeneration
is decellularization, in which the extracellular matrix (ECM) is isolated from its native cells and genetic material in order to
produce a natural scaffold. The ECM, which ideally retains its inherent structural, biochemical, and biomechanical cues, can
then be recellularized to produce a functional tissue or organ. While decellularization can be accomplished using chemical and
enzymatic, physical, or combinative methods, each strategy has both benefits and drawbacks.The focus of this review is to compare
the advantages and disadvantages of these methods in terms of their ability to retain desired ECM characteristics for particular
tissues and organs. Additionally, a few applications of constructs engineered using decellularized cell sheets, tissues, and whole
organs are discussed.

Source

  • BioMed Research International, 2017. Cairo, Egypt: Hindaw Publishing Corporation

Language

Item Type

Identifier

Unique identifying numbers for this article in the Digital Library or other systems.

Publication Information

  • Publication Title: BioMed Research International
  • Volume: 2017
  • Page Start: 1
  • Page End: 13
  • Peer Reviewed: Yes

Collections

This article is part of the following collection of related materials.

UNT Scholarly Works

Materials from the UNT community's research, creative, and scholarly activities and UNT's Open Access Repository. Access to some items in this collection may be restricted.

What responsibilities do I have when using this article?

When

Dates and time periods associated with this article.

Creation Date

  • April 30, 2017

Submitted Date

  • January 23, 2017

Accepted Date

  • April 12, 2017

Added to The UNT Digital Library

  • March 15, 2019, 11:51 a.m.

Usage Statistics

When was this article last used?

Yesterday: 0
Past 30 days: 2
Total Uses: 2

Interact With This Article

Here are some suggestions for what to do next.

Start Reading

PDF Version Also Available for Download.

International Image Interoperability Framework

IIF Logo

We support the IIIF Presentation API

Gilpin, Anna & Yang, Yong. Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications, article, April 30, 2017; Cairo, Egypt. (https://digital.library.unt.edu/ark:/67531/metadc1459148/: accessed March 21, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; crediting UNT College of Engineering.