Indocyanine green labeled with /sup 123/I for dynamic studies of the hepato-biliary system. [/sup 131/I, /sup 125/I]

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This report summarizes the results to develop an iodine-123 labeled agent for dynamic studies of the hepato-biliary system. Iodine-123 is an ideal nuclide for radiopharmaceuticals, because of its short half-life (T/sub /sup 1///sub 2// = 13.3 hr); its decay with a high abundance (83%) of 159 keV photons; and the reduced patient radiation exposure (a factor of 100 less than iodine-131). Indocyanine green, a tricarbanocyanine dye, was introduced by Heseltine and co-workers in 1956, has several characteristics which suggested that iodine-123 labeled ICG might be potentially useful for hepatic functional evaluation. The plasma clearance and biliary excretion kinetics of /sup ... continued below

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Pages: 24

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Lambrecht, R. M.; Ansari, A. N.; Wolf, A. P. & Atkins, H. L. January 1, 1975.

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Description

This report summarizes the results to develop an iodine-123 labeled agent for dynamic studies of the hepato-biliary system. Iodine-123 is an ideal nuclide for radiopharmaceuticals, because of its short half-life (T/sub /sup 1///sub 2// = 13.3 hr); its decay with a high abundance (83%) of 159 keV photons; and the reduced patient radiation exposure (a factor of 100 less than iodine-131). Indocyanine green, a tricarbanocyanine dye, was introduced by Heseltine and co-workers in 1956, has several characteristics which suggested that iodine-123 labeled ICG might be potentially useful for hepatic functional evaluation. The plasma clearance and biliary excretion kinetics of /sup 123/I-ICG (in dogs) will be compared to /sup 131/I-rose bengal and bromosulphalein labeled with iodine-125.

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Pages: 24

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Dep. NTIS

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  • Symposium on the biliary tract, Bordeaux, France, 4 Sep 1975

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  • Report No.: BNL-20958
  • Report No.: CONF-7509132-1
  • Office of Scientific & Technical Information Report Number: 7193112
  • Archival Resource Key: ark:/67531/metadc1446193

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Office of Scientific & Technical Information Technical Reports

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  • January 1, 1975

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  • Feb. 10, 2019, 8:45 p.m.

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  • March 7, 2019, 2:47 p.m.

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Lambrecht, R. M.; Ansari, A. N.; Wolf, A. P. & Atkins, H. L. Indocyanine green labeled with /sup 123/I for dynamic studies of the hepato-biliary system. [/sup 131/I, /sup 125/I], article, January 1, 1975; Upton, New York. (https://digital.library.unt.edu/ark:/67531/metadc1446193/: accessed March 23, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.