Comparison of normal and asthmatic subjects' responses to sulfate pollutant aerosols

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Epidemiological studies support an association between elevated levels of sulfates and acute respiratory disease. To determine if these pollutants produce airway hyperreactivity, 16 normal and 17 asthmatic subjects inhaled a control NaCl aerosol and the following sulfates: ammonium sulfate, sodium bisulfate, ammonium bisulfate, and sulfuric acid. A Lovelace generator produced particles with an average MMAD of approx. 1.0 ..mu..m (sigma/sub g/ approx. = 2.0) and concentrations of 0.1 and 1.0 mg/m/sup 3/. By double-blind randomization, all subjects breathed these aerosols for a 16-minute period. To determine if sulfate inhalation caused increased reactivity to a known bronchoconstrictor, all subjects inhaled carbachol ... continued below

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Pages: 7

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Utell, M. J.; Morrow, P. E. & Hyde, R. W. January 1, 1980.

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Description

Epidemiological studies support an association between elevated levels of sulfates and acute respiratory disease. To determine if these pollutants produce airway hyperreactivity, 16 normal and 17 asthmatic subjects inhaled a control NaCl aerosol and the following sulfates: ammonium sulfate, sodium bisulfate, ammonium bisulfate, and sulfuric acid. A Lovelace generator produced particles with an average MMAD of approx. 1.0 ..mu..m (sigma/sub g/ approx. = 2.0) and concentrations of 0.1 and 1.0 mg/m/sup 3/. By double-blind randomization, all subjects breathed these aerosols for a 16-minute period. To determine if sulfate inhalation caused increased reactivity to a known bronchoconstrictor, all subjects inhaled carbachol following each 16-minute exposure. Before, during, and after exposure, pulmonary function studies were performed. When compared to NaCl, sulfate (1 mg/m/sup 3/) produced significant reductions in airway conductance and flow rates in asthmatics. The two most sensitive asthmatics demonstrated changes even at 0.1 mg/m/sup 3/ sulfate. To a far more significant degree, the bronchoconstrictor action of carbachol was potentiated by sulfates more or less in relation to their acidity in normals and asthmatics.

Physical Description

Pages: 7

Notes

NTIS, PC A02/MF A01.

Source

  • 5. international symposium on inhaled particles, Cardiff, UK, 8 Sep 1980

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  • Report No.: UR-3490-1886
  • Report No.: CONF-8009111-1
  • Grant Number: AC02-76EV03490
  • Office of Scientific & Technical Information Report Number: 7096979
  • Archival Resource Key: ark:/67531/metadc1405114

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Office of Scientific & Technical Information Technical Reports

Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • January 1, 1980

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  • Jan. 23, 2019, 12:54 p.m.

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Utell, M. J.; Morrow, P. E. & Hyde, R. W. Comparison of normal and asthmatic subjects' responses to sulfate pollutant aerosols, article, January 1, 1980; United States. (https://digital.library.unt.edu/ark:/67531/metadc1405114/: accessed April 25, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.