Towards the timely detection of toxicants

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Article discussing the problem of enhancing the sensitivity of biosensors to the influence of toxicants, with an entropy method of analysis, denoted as CASSANDRA, for the specific purpose of studying non-stationary time series.

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6 p.

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Ignaccolo, Massimiliano; Grigolini, Paolo & Gross, Guenter W. April 2004.

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This article is part of the collection entitled: UNT Scholarly Works and was provided by UNT College of Arts and Sciences to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 43 times . More information about this article can be viewed below.

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Article discussing the problem of enhancing the sensitivity of biosensors to the influence of toxicants, with an entropy method of analysis, denoted as CASSANDRA, for the specific purpose of studying non-stationary time series.

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6 p.

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This is the accepted manuscript version of the article. Reprinted with permission from Elsevier Science Ltd., all rights reserved. The final definitive version is available here: http://dx.doi.org/10.1016/S0960-0779(03)00431-4

Abstract: We address the problem of enhancing the sensitivity of biosensors to the influence of toxicants, with an entropy method of analysis, denoted as CASSANDRA, recently invented for the specific purpose of studying non-stationary time series. The authors study the specific case where the toxicant is tetrodotoxin. This is a very poisonous substance that yields an abrupt drop of the rate of spike production at t approximately 170 minutes when the concentration of toxicant is 4 nanomoles. The CASSANDRA algorithm reveals the influence of toxicants thirty minutes prior to the drop in rate at a concentration of toxicant equal to 2 nanomoles. We argue that the success of this method of analysis rests on the adoption of a new perspective of complexity, interpreted as a condition intermediate between the dynamic and the thermodynamic state.

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  • Chaos, Solitons and Fractals, 2004, New York: Elsevier Science Ltd., pp. 87-93

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  • Publication Title: Chaos, Solitons and Fractals
  • Volume: 20
  • Issue: 1
  • Page Start: 87
  • Page End: 93
  • Peer Reviewed: Yes

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UNT Scholarly Works

The Scholarly Works Collection is home to materials from the University of North Texas community's research, creative, and scholarly activities and serves as UNT's Open Access Repository. It brings together articles, papers, artwork, music, research data, reports, presentations, and other scholarly and creative products representing the expertise in our university community.** Access to some items in this collection may be restricted.**

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  • April 2004

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  • Feb. 1, 2013, 9:58 a.m.

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  • April 1, 2015, 1:03 p.m.

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Ignaccolo, Massimiliano; Grigolini, Paolo & Gross, Guenter W. Towards the timely detection of toxicants, article, April 2004; [New York, New York]. (digital.library.unt.edu/ark:/67531/metadc139468/: accessed January 24, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.