Spontaneous coordinated activity in cultured networks: analysis of multiple ignition sites, primary circuits, and burst phase delay distributions

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This article discusses an analysis of multiple ignition sites, primary circuits, and burst phase delay distributions.

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11 p.

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Ham, Michael I.; Bettencourt, Luis; McDaniel, Floyd Del. (Floyd Delbert), 1942- & Gross, Guenter W. June 2008.

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This article is part of the collection entitled: UNT Scholarly Works and was provided by UNT College of Arts and Sciences to Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 54 times . More information about this article can be viewed below.

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  • Springer
    Place of Publication: [New York, New York]

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Description

This article discusses an analysis of multiple ignition sites, primary circuits, and burst phase delay distributions.

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11 p.

Notes

This is the post-print version version of an article whose final and definitive form has been published in the Journal of Computational Neuroscience © 2008 Springer. The final definitive version is available at: http://link.springer.com/article/10.1007%2Fs10827-007-0059-1

Abstract: All higher order central nervous systems exhibit spontaneous neural activity, though the purpose and mechanistic origin of such activity remains poorly understood. The authors quantitatively analyzed the ignition and spread of collective spontaneous electrophysiological activity in networks of cultured cortical neurons growing in microelectrode arrays. Leader neurons, which form a mono-synaptically connected primary circuit, and initiate a majority of network bursts were found to be a small subset of recorded neurons. Leader/follower firing delay times formed temporally stable positively skewed distributions. Blocking inhibitory synapses usually resulted in shorter delay times with reduced variance. These distributions are characterizations of general aspects of internal network dynamics and provide estimates of pair-wise synaptic distances. The resulting analysis produced specific quantitative constraints and insights into the activation patterns of collective neuronal activity in self-organized cortical networks, which may prove useful for models emulating spontaneously active systems.

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  • Journal of Computational Neuroscience, 2008, New York: Springer, pp. 346-357

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  • Publication Title: Journal of Computational Neuroscience
  • Volume: 24
  • Issue: 3
  • Page Start: 346
  • Page End: 357
  • Peer Reviewed: Yes

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  • June 2008

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  • Feb. 1, 2013, 9:58 a.m.

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  • April 1, 2014, 1:40 p.m.

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Ham, Michael I.; Bettencourt, Luis; McDaniel, Floyd Del. (Floyd Delbert), 1942- & Gross, Guenter W. Spontaneous coordinated activity in cultured networks: analysis of multiple ignition sites, primary circuits, and burst phase delay distributions, article, June 2008; [New York, New York]. (digital.library.unt.edu/ark:/67531/metadc139463/: accessed October 17, 2017), University of North Texas Libraries, Digital Library, digital.library.unt.edu; crediting UNT College of Arts and Sciences.