Enhanced fermentation systems with continuous removal of inhibitory products

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A variety of advanced bioreactors are being developed to improve production of fuels, solvents, organic acids, and other fermentation products. A major limitation of microbial fermentations is the dilute aqueous product streams that result, largely due to inhibition of the microbes by the desired products. If these inhibitory products can be removed during the ongoing fermentation, the overall rates, yields, and net product formation may be increased. Simultaneous fermentation and separation have been tested with different separation techniques, such as adsorption, liquid extraction, pervaporation, membrane separations, distillation, and others. These separations can occur directly in situ within the fermentor or ... continued below

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5 p.

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Davison, B. H. & Kaufman, E. N. June 1, 1994.

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Description

A variety of advanced bioreactors are being developed to improve production of fuels, solvents, organic acids, and other fermentation products. A major limitation of microbial fermentations is the dilute aqueous product streams that result, largely due to inhibition of the microbes by the desired products. If these inhibitory products can be removed during the ongoing fermentation, the overall rates, yields, and net product formation may be increased. Simultaneous fermentation and separation have been tested with different separation techniques, such as adsorption, liquid extraction, pervaporation, membrane separations, distillation, and others. These separations can occur directly in situ within the fermentor or indirectly using a sidestream separator with recycle of the unused substrate. These approaches are briefly reviewed. At Oak Ridge National Laboratory (ORNL), we have investigated two modified immobilized-cell fluidized-bed bioreactors (FBRs) to remove the inhibitory product directly from the continuous fermentation. One involves the separation by adsorption of tactic acid, and the other uses liquid solvent extraction for the production of butanol. Keywords: extractive fermentation, in situ separation, adsorption, tactic acid, butanol.

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5 p.

Notes

OSTI as DE94012751; Paper copy available at OSTI: phone, 865-576-8401, or email, reports@adonis.osti.gov

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  • 5. corn utilization,St. Louis, MO (United States),8-10 Jun 1994

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  • Other: DE94012751
  • Report No.: CONF-9406177--1
  • Grant Number: AC05-84OR21400
  • Office of Scientific & Technical Information Report Number: 10156744
  • Archival Resource Key: ark:/67531/metadc1317193

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Reports, articles and other documents harvested from the Office of Scientific and Technical Information.

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  • June 1, 1994

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  • Nov. 3, 2018, 11:47 a.m.

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  • Nov. 13, 2018, 9:07 p.m.

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Davison, B. H. & Kaufman, E. N. Enhanced fermentation systems with continuous removal of inhibitory products, article, June 1, 1994; Tennessee. (https://digital.library.unt.edu/ark:/67531/metadc1317193/: accessed April 18, 2019), University of North Texas Libraries, Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.