Nuclear medicine program progress report for quarter ending March 31, 1994 Metadata

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  • Main Title Nuclear medicine program progress report for quarter ending March 31, 1994


  • Author: Knapp, F. F. Jr.
    Creator Type: Personal
  • Author: Ambrose, K. R.
    Creator Type: Personal
  • Author: Beets, A. L.
    Creator Type: Personal
  • Author: Lambert, C. R.
    Creator Type: Personal
  • Author: McPherson, D. W.
    Creator Type: Personal
  • Author: Mirzadeh, S.
    Creator Type: Personal
  • Author: Luo, H.
    Creator Type: Personal


  • Sponsor: United States. Department of Energy.
    Contributor Type: Organization
    Contributor Info: USDOE, Washington, DC (United States)


  • Name: Oak Ridge National Laboratory
    Place of Publication: Tennessee
    Additional Info: Oak Ridge National Lab., TN (United States)


  • Creation: 1994-05-01


  • English


  • Content Description: The authors` new radioiodinated ``IQNP`` agent, an analogue of ``4-IQNB``, has a high affinity for the muscarinic-cholinergic receptor (m-AChR). Iodine is stabilized in ``IQNP`` by attachment as a vinyl iodide. To evaluate the potential usefulness of a [Br-76]-labeled analogue as a candidate for positron emission tomography (PET), they have synthesized the trans-3-bromopropenyl analogue (BrQNP) and evaluated its ability in vivo to block uptake of [I-125]-Z-(R,R)-IQNP. Reaction of bromine with the trans-tributylstannyl substrate prepared from ethyl -{alpha}-hydroxy -{alpha}-phenyl-{alpha}-(1-propyn-3-yl)acetate, followed by column purification and transesterification with (R,S)-3-quinuclidinol gave BrQNP. Female rats were pre-treated with the oxalate salt of BrQNP one hour prior to I.V. injection of [I-125]-IQNP. While the brain and heart uptake in BrQNP pre-treated animals was significantly decreased, the control animals showed the expected high uptake of IQNP in these tissues. The ease of preparation and ability to block m-AChR suggest that [Br-76]-labeled BrQNP is a potential candidate for PET studies. In this report, the authors also summarize their current on-going collaborative studies assessing the usefulness of various rhenium-188-labeled therapeutic agents. In addition, collaborative programs have been established to evaluate rhenium-188-labeled particles for treatment of arthritis (synovectomy), treatment of bone pain resulting from cancer metastheses with rhenium-188-phosphonates (palliation), and other applications.
  • Physical Description: 14 p.


  • Keyword: Research Programs
  • Keyword: Radioimmunotherapy
  • Keyword: Nuclear Medicine
  • Keyword: Radiopharmaceuticals
  • STI Subject Categories: 62 Radiology And Nuclear Medicine
  • Keyword: Progress Report
  • Keyword: Therapeutic Uses
  • Keyword: Diagnostic Uses 550601
  • Keyword: Chemical Preparation
  • Keyword: Unsealed Radionuclides In Diagnostics
  • Keyword: Unsealed Radionuclides In Therapy
  • Keyword: Uptake
  • STI Subject Categories: 550604


  • Other Information: PBD: 1 May 1994


  • Name: Office of Scientific & Technical Information Technical Reports
    Code: OSTI


  • Name: UNT Libraries Government Documents Department
    Code: UNTGD

Resource Type

  • Report


  • Text


  • Other: DE94011796
  • Report No.: ORNL/TM--12707
  • Grant Number: AC05-84OR21400
  • DOI: 10.2172/10151067
  • Office of Scientific & Technical Information Report Number: 10151067
  • Archival Resource Key: ark:/67531/metadc1313353


  • Display Note: OSTI as DE94011796; Paper copy available at OSTI: phone, 865-576-8401, or email,