Photo-Magnetic Irradiation-Mediated Multimodal Therapy of Neuroblastoma Cells Using a Cluster of Multifunctional Nanostructures

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This article implements a safer and alternative multimodal therapeutic strategy involving simultaneous optical and oscillating (AC) magnetic field stimulation of a multifunctional nanocarrier system to guide neuroblastoma cell destruction.

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17 p.

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Atluri, Rohini; Atmaramani, Rahul; Tharaka, Gamage; McCallister, Thomas; Peng, Jian; Diercks, David et al. September 29, 2018.

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This article is part of the collection entitled: UNT Graduate Student Works and was provided by the UNT College of Engineering to the UNT Digital Library, a digital repository hosted by the UNT Libraries. It has been viewed 70 times. More information about this article can be viewed below.

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UNT College of Engineering

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This article implements a safer and alternative multimodal therapeutic strategy involving simultaneous optical and oscillating (AC) magnetic field stimulation of a multifunctional nanocarrier system to guide neuroblastoma cell destruction.

Physical Description

17 p.

Notes

Abstract: The use of high intensity chemo-radiotherapies has demonstrated only modest
improvement in the treatment of high-risk neuroblastomas. Moreover, undesirable drug specific
and radiation therapy-incurred side effects enhance the risk of developing into a second cancer
at a later stage. In this study, a safer and alternative multimodal therapeutic strategy involving
simultaneous optical and oscillating (AC) magnetic field stimulation of a multifunctional nanocarrier
system has successfully been implemented to guide neuroblastoma cell destruction. This novel
technique permitted the use of low-intensity photo-magnetic irradiation and reduced the required
nanoparticle dose level. The combination of released cisplatin from the nanodrug reservoirs and
photo-magnetic coupled hyperthermia mediated cytotoxicity led to the complete ablation of the B35
neuroblastoma cells in culture. Our study suggests that smart nanostructure-based photo-magnetic
hybrid irradiation is a viable approach to remotely guide neuroblastoma cell destruction, which may
be adopted in clinical management post modification to treat aggressive cancers.

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  • Nanomaterials, 2018. Basel, Switzerland: Multidisciplinary Digital Publishing Institute

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  • Publication Title: Nanomaterials
  • Volume: 8
  • Page Start: 1
  • Page End: 17
  • Peer Reviewed: Yes

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UNT Graduate Student Works

This collection houses graduate student works other than theses and dissertations. All materials have been previously accepted by a professional organization or approved by a faculty mentor. The collection includes, but is not limited to projects or problems in lieu of thesis, supplemental files associated with theses and dissertations, posters, recitals, presentations, articles, reviews, book chapters, exhibitions, and artwork. Some items in this collection are restricted to use by the UNT community.

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  • September 29, 2018

Submitted Date

  • July 24, 2018

Accepted Date

  • August 25, 2018

Added to The UNT Digital Library

  • Oct. 31, 2018, 6:58 p.m.

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Atluri, Rohini; Atmaramani, Rahul; Tharaka, Gamage; McCallister, Thomas; Peng, Jian; Diercks, David et al. Photo-Magnetic Irradiation-Mediated Multimodal Therapy of Neuroblastoma Cells Using a Cluster of Multifunctional Nanostructures, article, September 29, 2018; Basel, Switzerland. (https://digital.library.unt.edu/ark:/67531/metadc1310116/: accessed June 25, 2024), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT College of Engineering.

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