Joint National Institute for Health-Atomic Energy Commission Zonal Centrifuge Development Program, Semiannual Report for Period July 1 - December 31, 1962

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Description

This technical report describes development work done on zonal centrifuge systems at the Oak Ridge National Laboratory and the Oak Ridge Gaseous Diffusion Plant during the period July 1 to December 31, 1962 under the Joint National Institute for Health-Atomic Energy Commission Zonal Centrifuge Development Program. A basic purpose of this project is to develop new methods for isolating virus particles associated with cancerous cells and tissues. Three classes of rotor systems capable of separating particles ranging in size from whole animal or plant cells to protein or nucleic acid molecules on the basis of either sedimentation rate or density … continued below

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89 pages : illustrations

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Anderson, N. G. March 4, 1963.

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  • Main Title: Joint National Institute for Health-Atomic Energy Commission Zonal Centrifuge Development Program, Semiannual Report for Period July 1 - December 31, 1962
  • Series Title: ORNL (Series)
  • Series Title: Oak Ridge National Laboratory Reports
  • Added Title: Oak Ridge National Laboratory Report ORNL-3415

Description

This technical report describes development work done on zonal centrifuge systems at the Oak Ridge National Laboratory and the Oak Ridge Gaseous Diffusion Plant during the period July 1 to December 31, 1962 under the Joint National Institute for Health-Atomic Energy Commission Zonal Centrifuge Development Program. A basic purpose of this project is to develop new methods for isolating virus particles associated with cancerous cells and tissues. Three classes of rotor systems capable of separating particles ranging in size from whole animal or plant cells to protein or nucleic acid molecules on the basis of either sedimentation rate or density alone have been developed. Experiments with phage particles indicate the feasibility of large-scale virus isolation by continuous-flow centrifugation, followed by isopycnic banding in cesium chloride and velocity sedimentation in sucrose - all steps being carried out sequentially in the same rotor. Zonal rotors using the reorienting gradient principle for molecular separations have been tested to 141,000 rpm (formula). Previous work on zonal centrifugation and future plans for this program are discussed.

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89 pages : illustrations

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Digitized from microopaque cards (3).

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  • SuDoc Number: Y 3.At 7:22/ORNL-3415
  • Report No.: ORNL-3415
  • Accession or Local Control No: metadc1257304
  • Archival Resource Key: ark:/67531/metadc1257304

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  • March 4, 1963

Added to The UNT Digital Library

  • June 18, 2021, 7:16 a.m.

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  • Feb. 1, 2023, 10:06 a.m.

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Thumbnail image of item number 1 in: 'Joint National Institute for Health-Atomic Energy Commission Zonal Centrifuge Development Program, Semiannual Report for Period July 1 - December 31, 1962'.
Thumbnail image of item number 2 in: 'Joint National Institute for Health-Atomic Energy Commission Zonal Centrifuge Development Program, Semiannual Report for Period July 1 - December 31, 1962'.
Thumbnail image of item number 3 in: 'Joint National Institute for Health-Atomic Energy Commission Zonal Centrifuge Development Program, Semiannual Report for Period July 1 - December 31, 1962'.
Thumbnail image of item number 4 in: 'Joint National Institute for Health-Atomic Energy Commission Zonal Centrifuge Development Program, Semiannual Report for Period July 1 - December 31, 1962'.

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Anderson, N. G. Joint National Institute for Health-Atomic Energy Commission Zonal Centrifuge Development Program, Semiannual Report for Period July 1 - December 31, 1962, report, March 4, 1963; Oak Ridge, Tennessee. (https://digital.library.unt.edu/ark:/67531/metadc1257304/: accessed June 11, 2026), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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