Reutilization of DNA-Thymine, and Conversion of RNA-Pyrimidines for DNA-Thymine, in Normal Rat Bone Marrow Studies with Tritiated Nucleosides

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Description

If one injects into an animal H3-thymidine, 50% of it is incorporated into deoxyribonucleic acid (DNA), within approximately 30 to 45 minutes, while the rest is catabolized. A storage of H3-thymidine for later incorporation into DNA does not occur, on the basis of available evidence. Once incorporated, the label remains bound to DNA until cell death and no unequivocal evidence has as yet been presented to indicate metabolic renewal or intracellular turnover of the DNA molecule. The loss of labeled DNA from the bone marrow is therefore directly influenced by the rate of proliferation of the various cell types with … continued below

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Feinendegen, L. E.; Bond, V. P.; Cronkite, E. P. & Hughes, W. L. November 13, 1963.

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  • Main Title: Reutilization of DNA-Thymine, and Conversion of RNA-Pyrimidines for DNA-Thymine, in Normal Rat Bone Marrow Studies with Tritiated Nucleosides
  • Series Title: BNL (Series)
  • Series Title: Brookhaven National Laboratory Reports
  • Added Title: Brookhaven National Laboratory Report BNL-7365

Description

If one injects into an animal H3-thymidine, 50% of it is incorporated into deoxyribonucleic acid (DNA), within approximately 30 to 45 minutes, while the rest is catabolized. A storage of H3-thymidine for later incorporation into DNA does not occur, on the basis of available evidence. Once incorporated, the label remains bound to DNA until cell death and no unequivocal evidence has as yet been presented to indicate metabolic renewal or intracellular turnover of the DNA molecule. The loss of labeled DNA from the bone marrow is therefore directly influenced by the rate of proliferation of the various cell types with release of mature cells into the peripheral blood.

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  • November 13, 1963

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Thumbnail image of item number 1 in: 'Reutilization of DNA-Thymine, and Conversion of RNA-Pyrimidines for DNA-Thymine, in Normal Rat Bone Marrow Studies with Tritiated Nucleosides'.
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Thumbnail image of item number 3 in: 'Reutilization of DNA-Thymine, and Conversion of RNA-Pyrimidines for DNA-Thymine, in Normal Rat Bone Marrow Studies with Tritiated Nucleosides'.
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Feinendegen, L. E.; Bond, V. P.; Cronkite, E. P. & Hughes, W. L. Reutilization of DNA-Thymine, and Conversion of RNA-Pyrimidines for DNA-Thymine, in Normal Rat Bone Marrow Studies with Tritiated Nucleosides, report, November 13, 1963; Washington D.C.. (https://digital.library.unt.edu/ark:/67531/metadc1255905/: accessed June 8, 2026), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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