Hematological Effects of Whole Body Irradiation

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The development of nuclear arms added the effects of ionizing radiation to the direct and indirect mechanical, chemical or thermal hazards of "conventional" weapons. The biological effects of ionizing radiation are the result of absorption of energy and the morphologically recognizable damage is poorly understood. Although new in their use in weapons and difficult to evaluate in their consequences, ionizing radiations are by no means new to physicians. Furthermore, medical experience has shown that clinical consequences of radiation injury are similar to those with which the clinician has to deal with every day in the treatment of neoplastic disorders and … continued below

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Fliedner, T. M. & Cronkite, E. P. October 15, 1963.

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The development of nuclear arms added the effects of ionizing radiation to the direct and indirect mechanical, chemical or thermal hazards of "conventional" weapons. The biological effects of ionizing radiation are the result of absorption of energy and the morphologically recognizable damage is poorly understood. Although new in their use in weapons and difficult to evaluate in their consequences, ionizing radiations are by no means new to physicians. Furthermore, medical experience has shown that clinical consequences of radiation injury are similar to those with which the clinician has to deal with every day in the treatment of neoplastic disorders and its complications. Soon after the discovery of x-rays by Roentgen and of the phenomenon of radioactivity by Bequerrel in the last decade of the last decade of the 19th century, it was found that ionizing radiation can produce marked biological effects by interfering with cell- and organ functions. Senn and Hussey were the first to effectively treat leukemia by this means. This, since about 60 years, ionizing radiation has been a powerful tool in the hands of physicians both in diagnostic procedures and for therapy of malignant disease. It should not be forgotten however, that the price paid for this contribution of outstanding importance was high. Long before any nuclear weapons were used, a long list of fatalities and injuries among physicians, investigators, technicians and nurses, witnessed the possible consequences of radiation exposure. However, the number of lives saved through the use of ionizing radiation exceed greatly the number of lives ever lost through the harmful effects of radiation.

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  • October 15, 1963

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  • Feb. 5, 2022, 9:57 a.m.

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  • Jan. 24, 2023, 3:14 a.m.

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Fliedner, T. M. & Cronkite, E. P. Hematological Effects of Whole Body Irradiation, report, October 15, 1963; Washington D.C.. (https://digital.library.unt.edu/ark:/67531/metadc1255870/: accessed May 13, 2026), University of North Texas Libraries, UNT Digital Library, https://digital.library.unt.edu; crediting UNT Libraries Government Documents Department.

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